Bausch-lomb Incorporated

Allergan, Inc.

David A Marsh

David J Heiler

Matthew S Jonasse

Wendy M Blanda

Joseph G Vehige

Peter A Simmons

Suzanne F Groemminger

Michelle H Luu

Hongwen Ma Rivers

Nimai C De

Jill S Rogalskyj

Rick Panicucci

Steven S Matsumoto

Bereth J Beard

Liu Haixia

Disclosed herein are autoclavable formulations of cyclosporin A Form 2, methods of making such formulations, and methods of treating diseases of the eye with such formulations.

Autoclavable suspensions of cyclosporin A Form 2

A method of treating contact lenses comprising the use of an iodine-chromophore to indicate neutralization of oxidative disinfectants.

Method for indicating neutralization of contact lens disinfecting

A composition and method for cleaning and disinfecting of contact lenses that employ an electrical field applied to a lens that causes contaminating deposits to migrate therefrom is described. The composition of the invention includes a pair of component materials having different electrochemical potentials wherein the materials are substantially contained in a form wherein each material remains sufficiently physically separated when in contact with opposite sides of the lens such that the difference in electrochemical potential between the two materials is sufficient to cause charged contaminating deposits to migrate from the lens. The method of the invention requires placing a contaminated lens between a pair of component materials having different electrochemical potentials wherein physical separation is maintained, preferably, by including one of the components in a gel while the other component is in solution or another gel. Preferably, one component of the pair of materials is an oxidizing agent while the second component is a reducing agent. An example of a suitable pair is hydrogen peroxide suspended in a carbopol gel and a solution of sodium thiosulfate, as the reducing agent. A lens is coated with the oxidant gel, placed in the reductant solution and held at room temperature for 2-4 hours, wherein the electrochemical field established between the pair achieves about a 29% protein removal.

Cleaning hydrophilic contact lenses by electrochemical means

Contact lenses are cleaned by contacting the lenses with a composition containing an effective amount of one or more cyclodextrins. The compositions can also be employed at elevated temperatures or may contain suitable antimicrobial agents in order to simultaneously clean and disinfect the lenses.

Method and composition for cleaning contact lenses with cyclodextrins

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Rochester, NY, United States of America

David A Marsh