Genentech, Inc.

David A Lawrence

William I Wood

Audrey Goddard

David Botstein

Margaret Ann Roy

Diane Pennica

Austin L Gurney

Avi J Ashkenazi

Kenneth J Hillan

Robert L Cohen

Arnold J Levine

Daniel Tumas

Kyung Jin Kim

Robert Maurice Pitti

Cary Dean Austin

Kelly H Dodge

Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

WISP polypeptides and nucleic acids encoding same

The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.

Methods and materials for observing apoptosis

The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

Cardiotrophin-1 compositions and methods for the treatment of tumor

A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

Antibodies to DcR3 Polypeptide, a TNFR Homolog

Cardiotrophin-1 defective mouse

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San Francisco, CA, United States of America

David A Lawrence