G.d. Searle & Company

David A Jones, Jr

James M Schlatter

Robert H Mazur

Donald W Hansen, Jr

Richard A Mikulec

Judith A Reuter

The invention relates to tetrapeptides of the formula I: ##STR1## which are useful as renin inhibition/antihypertensive agents.

Tetrapeptide amides in the treatment of hypertension

The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.

Enkephalin analogs

The invention relates to novel enkephalin derivatives which are useful as analgesic agents of the formula: ##STR1##

Enkephalin derivatives

An enkephalin derivative represented by the formula

2,6-C-Dimethyltyrosine.sup.1 -D-amino acid.sup.2 -.epsilon.-amino

Methionine.sup.5 -enkephalin sulfoxides and sulfones having agonist activity at opiate receptors are disclosed herein. These sulfoxides and sulfones are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

Methionine.sup.5 -enkephalin sulfoxides and sulfones

Analogs of methionine.sup.5 -enkephalin and leucine.sup.5 -enkephalin wherein the L-phenylalanyl residue in position 4 has been substituted by various other amino acid residues are disclosed herein. These analogs exhibit agonist activity at opiate receptor sites and are thus useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

4-Substituted enkephalin derivatives

Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

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Evanston, IL, United States of America

David A Jones, Jr