Corixa Corporation

Glaxosmithkline Biologicals Sa

Other

Berner International Corporation

Glaxosmithkline LLC

Ribi Immunochem Research, Inc.

David A Johnson

C Gregory Sowell

Helene G Bazin-Lee

Jory R Baldridge

David H Persing

Rong Wang

Christopher W Cluff

J Terry Ulrich

Michael J Lacy

Richard Thomas Crane

David Burkhart

Craig L Johnson

Philip M Thomas, Jr

Jay T Evans

Laura S Bess

Diane Mary Coe

Charlotte Jane Mitchell

Patricia A Weber

Michael Cochran

Laurie A Minns

Melinda M Hutton

William S Bowen

Nupur Dutta

Gary T Elliot

Helene G Bazin

Lance L Ercanbrack

Kent B Gustin

Greg Sowell

The herein described Adaptive Ergonomic Positioning device ('AEPD') relates generally to the field of surgery and other medical or healthcare procedures. The AEPD can be adapted for use with most standard surgical tables and surgical chairs where the patient must be positioned prone during a particular procedure. The AEPD may also be used for certain procedures where the patient may be positioned supine. The AEPD support assemblies are highly adjustable and deliver improved ergonomics for both patients and providers. Patients of different morphology can be comfortably positioned in prone with their head and neck in a neutral position, and shoulders in a forward flexed, slightly internally rotated position. The AEPD can be adjusted to accommodate patients with neck and shoulder mobility restrictions, without any effect on provider accessibility to the surgical or treatment site.

Adaptive ergonomic positioning device

This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants.

Imidazoquinoline derivatives and their use in therapy

The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)-active and toll-like receptor (TLR8)-active imidazoquinolines and oxoadenines.

Phospholipidation of imidazoquinolines and oxoadenines

The present invention provides novel phospholipidated imidazoquinolines as TLR7 and TLR8 agonists, pharmaceutical compositions, therapeutic uses and processes for preparing the same.

Pegylated imidazoquinolines as TLR7 and TLR8 agonists

The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)&#x2014;active and toll-like receptor (TLR8)&#x2014;active imidazoquinolines and oxoadenines.

The present invention provides novel phospholipidated imidazoquinolines of formula (I) as TLR7 and TLR8 agonists, pharmaceutical compositions, therapeutic uses and processes for preparing the same. 

Pegylated imidazoquinolines

An air curtain resistant heating system including multiple independent heating coils integrated on blower housing. The multiple heating coils defining a pre-inflow venturi air pattern for increased heat transfer before fan cage internal flow vortex dependent on housing cage opposed openings. Coil orientation placement assures limited impact to effect blower pressure and therefore minimizes loss of air performance parameters while heating air flow in a pre-inflow venturi air pattern. Multiple phase electrical supply for multiple paired heating coils positioned in corresponding multiple blower fan units in an air curtain assembly.

Integrated venturi heating elements for air curtains

There is provided a composition comprising an aminoalkyl glucosaminide phosphate compound or a pharmaceutically salt thereof and a buffer for use as an immunomodulator.

Composition for buffered aminoalkyl glucosaminide phosphate compounds and its use for enhancing an immune response

Provided are novel lipidated oxoadenines which are useful as immunostimulators and adjuvants and are shown to be inducers of interferon-a and other immunostimulatory cytokines.

Lipidated oxoadenine derivatives

The compounds of the subject invention are adjuvant molecules that comprise an imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens.

Lipidated imidazoquinoline derivatives

The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

Method for inducing a TRIF-bias

The compounds of the subject invention are adjuvant molecules that comprise a imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens.

The present invention relates to compounds of formula (I): wherein;

Purine derivatives and their pharmaceutical uses

An air curtain resistant heating system including multiple heating coils integrated within blower fan cages. The multiple heating coils defining an inflow venture air pattern for increased heat transfer and fan cage internal flow vortex dependent on coil flow conveyance. Coil orientation placement assures limited impact to effect blower pressure and therefore minimizes loss of air performance parameters. Multiple phase electrical supply for multiple paired heating coils positioned in corresponding multiple blower fan units in an air curtain assembly.

Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.

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Hamilton, MT, United States of America

David A Johnson