Schering Aktiengesellschaft

David A Henderson

Rudolf Wiechert

Sybille Beier

Walter Elger

Yukishige Nishino

Rolf Bohlmann

Gunter Neef

Eckhard Ottow

Peter Strehlke

Martin Schneider

Ralph Rohde

Guenter Neef

Henry Laurent

Gerhard Sauer

Klaus Annen

Ulrich Kerb

Helmut Hofmeister

Wolfgang Losert

Hermann Kunzer

Eckard Otto

Alain L De Week

Friedrich E Maly

Juergen Bardenhagen

A process of cyclizing compounds of formula II ##STR1## wherein K, V', R.sup.1 and 1 are as herein defined, is described whereby a compound of formula IVa is produced ##STR2## wherein K, V', R.sup.1, Q, S and 1 are as herein defined. The compounds of formula IVa are useful intermediates in the production of compounds of formula I ##STR3## wherein ring A, B, G, V, Z, R.sup.1 and R.sup.2 are as herein defined.

Process for preparing 19,11.beta.-bridged steroids

The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least on a alkyl substituent,

Cycloalkylene azoles, and their use as aromatase inhibitors

The disclosure relates to cycloalkylene azoles of general Formula I ##STR1## wherein ##STR2## is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent,

Cycloalkylene azoles and their use as aromatase inhibitors

Disclosed are novel 14,17.alpha.-etheno- and -ethanoestratrienes according to general Formula I ##STR1## wherein X is a --CH.sub.2 --CH.sub.2 or ##STR2## R.sup.1 is a hydrogen atom, a C.sub.1 - to C.sub.15 -acyl, benzoyl, C.sub.1 - to C.sub.15 -alkyl, C.sub.3 - to C.sub.9 -cycloalkyl or alkylcycloalkyl group, and

14,17.alpha.-etheno- and -ethanoestratrienes, processes for the

Cycloalkylene azoles and pharmaceutical preparations obtained therefrom

New 19,11.beta.-bridged steroids of the general formula I ##STR1## where R.sup.1 stands for a methyl or ethyl radical,

19,11 .beta.-bridged steroids, their manufacture and pharmaceutical

11 .beta.-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping ##STR2## R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms,

.beta.-(4-isopropenylphenyl)estra-4,9-dienes, their production, and

13-alkyl-11.beta.-phenyl-gonanes of general formula I ##STR1## wherein A and B together stand for an oxygen atom, a CH.sub.2 group or a second bond between carbon atoms 9 and 10,

11 .beta.-phenyl-gonanes, their manufacture and pharmaceutical

The invention relates to N-substituted imidazoles, processes for their production as well as their use in pharmaceutical agents. The compounds according to the invention have aromatase-inhibiting properties.

N-substituted imidazoles and their use in pharmaceutical agents

N-substituted imidazoles, as well as their use in pharmaceutical agents

A 3-methylene-4-androsten-17-one of formula I ##STR1## wherein R.sub.a represents a hydrogen atom or a saturated or unsaturated straight-chain or branched-chain, optionally substituted alkyl radical with 1-6 carbon atoms, in which R.sub.a is in the alpha- or beta-position, and

3-methylene-4-androsten-17-ones, process for their production and

The invention relates to N-substituted imidazoles of the formula, ##STR1## processes for their production as well as their use in pharmaceutical agents. The compounds according to the invention have aromatase-inhibiting properties and are suitable for therapy of estrogen-caused diseases.

N-substituted imidazoles as aromatase inhibitors

A method for the early detection of a pregnancy comprises determination of EPF in the blood or urine or in a biochemical derivative of the blood or urine of pregnant women, by measuring the influence of EPF on the production of electronically excited states or radicals, especially oxygen radicals, or their secondary products, in leukocyte or cell line preparations. The method can also be used to determine gonadal tumors.

Pregnancy test with EPF

1-Methyl-15.alpha.-(1-oxyalkyl)androsta-1,4-diene-3,17-diones of general Formula I ##STR1## wherein R.sup.1 is a hydrogen atom or an acyl group of 1-10 carbon atoms,

1-methyl-15.alpha.-(1-oxyalkyl)androsta-1,4-diene-3,17-diones, processes

11.beta.-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H;

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Berlin, Germany

David A Henderson