Uchicago Argonne, LLC

David A Ehst

James L Willit

Jerry A Nolen, Jr

David Alan Rotsch

James L Bailey

Michael Alexander Brown

Ronald T Kmak

Nicholas A Smith

Sergey A Chemerisov

Delbert L Bowers

James J Grudzinski

The present invention provides a target unit and a sublimation apparatus suitable for use in a method for producing Cu67 radioisotope suitable for use in medical applications. The apparatus comprises a sublimation tube with one open end. The sublimation tube contains an ingot comprising Zn68 and Cu67 in a ceramic capsule contacting a closed end the sublimation tube. A removable vacuum dome is sealable over the open end of the sublimation tube so that interior of the apparatus can be placed under vacuum.

Apparatus for producing copper-67 radioisotope for medical applications

A system for producing and harvesting radioisotopes is provided, the system having a converter housing defining a first beam window; a converter carrier and cartridge in slidable communication with the converter housing; a target housing positioned downstream from the converter housing, the target housing defining a second beam window; and a target carrier in slidable communication with the target housing.

Radioisotope target station

A target unit for producing Cu67 radioisotope is described herein, and comprises a cage body releasably coupled to a screw-on cap; and a ceramic capsule containing a solid Zn68 target ingot and having one open end and one closed end and defining an interior chamber for the target ingot. The ceramic capsule is releasably contained between the cage body and the screw-on cap with a lid disposed on the open end of the capsule and a washer positioned between the lid and the screw-on cap. The screw-on cap and the washer provide a water-tight seal between the lid and the capsule. The interior of the capsule is in intimate physical contact with the target ingot; and the Zn68 of the target ingot is free of traces of residual oxygen that interfere with contact of the Zn68 to the capsule.

Target unit with ceramic capsule for producing cu-67 radioisotope

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target within a sealed ceramic capsule with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g. chemical and or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc in a ceramic sublimation tube to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means.

Methods for producing Cu-67 radioisotope with use of a ceramic capsule for medical applications

The present invention provides a method for producing Cu67 radioisotope suitable for use in medical applications. The method comprises irradiating a metallic zinc-68 (Zn68) target with a high energy gamma ray beam. After irradiation, the Cu67 is isolated from the Zn68 by any suitable method (e.g., chemical and/or physical separation). In a preferred embodiment, the Cu67 is isolated by sublimation of the zinc (e.g., at about 500-700&#xb0; C. under reduced pressure) to afford a copper residue containing Cu67. The Cu67 can be further purified by chemical means (i.e., dissolution in acid, followed by ion exchange).

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Downers Grove, IL, United States of America

David A Ehst