Tate & Lyle Technology Limited

David A Dentel

James Edwin Wiley, Jr

David Harold Coleman

John Kerr

Edward Micinski

Duane Leinhos

Wayne N Boutzale

Mohamad R Jaber

Thomas A Eilers

Duane A Leinhos

A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes: forming an extraction medium including an acid-extracting tin species and an extraction solvent that is immiscible with the tertiary amide solvent; subsequently contacting the liquid with the extraction medium, forming a phase including a de-acidified tertiary amide solvent and a phase including the extraction solvent; and removing the phase including the extraction solvent, to afford a liquid including the de-acidified tertiary amide solvent. The acid-extracting tin species is one or more tin species obtained by reaction of a di(hydrocarbyl) tin oxide with less than one equivalent of a carboxylic acid, or tin species obtainable by reaction of a 1,3-diacyloxy-1,1,3,3-tetra-(hydrocarbyl)distannoxane with an aqueous base. A method of preparing a sucralose-6-acylate includes uses the foregoing method to remove a carboxylic acid from a liquid including a tertiary amide solvent and the sucralose-6-acylate.

Extraction of carboxylic acids with tin compounds

A method for the chlorination of a sucrose-6-acylate to produce a 4,1',6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-galactosucrose-&#x3b2;-acylate wherein said method comprises: (i) reacting the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide in order to chlorinate the 4, V and 6&#x2032; positions of the sucrose-6-acylate; and (ii) quenching the product stream of (i) to produce a 4,1&#x2032;,6&#x2032;-trichloro-4,1&#x2032;,6&#x2032;-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of the tertiary amide is removed.

Chlorination of sucrose-6-esters

The present invention provides a method for producing sucralose from a feed stream including a sucrose-6-acylate in a reaction vehicle. The method includes:

Method for the production of sucralose

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Singapore, Singapore

David A Dentel