Pfizer Corporation

David A Clark

Bernard Hulin

Steven Wayne Goldstein

James P Rizzi

Gerald F Holland

Michael Ross Johnson

Robert L Dow

Optically pure thiazolidinedione alcohols and ethers, and synthetic intermediates for preparing said alcohols and ethers. These compounds have utility as hypoglycemic and hypocholesterolemic agents.

Hypoglycemic thiazolidinediones and intermediates

Compounds of the formulae ##STR1## where R is cycloalkyl or aryl; R.sub.1 is alkyl, X is O or C.dbd.O; A is O or S; and B is N or CH are useful as hypoglycemic agents.

Oxazolidinedione hypoglycemic agents

Thiazolidinedione derivatives as hypoglycemic agents

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and B are each independently CH;

Thiazolidinedione hypoglycemic agents

Hypoglycemic thiazolidine-2,4-dione derivatives ##STR1## wherein the dotted line represents a bond or no bond;

Hypoglycemic thiazolidinedione derivatives

Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond; A and dB are each independently CH or N, with the proviso that when A or B is N, the other is CH;

Hypoglycemic thiazolidine-2,4-derivatives ##STR1## wherein the dotted line represents a bond or no bond; V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S;

Oxazolidin-2-one derivatives as hypoglycemic agents

The present invention relates to certain compounds of the formula ##STR1## wherein the broken line is a bond or no bond, and the pharmaceutically acceptable cationic salts thereof having utility as hypoglycemic and anti-atherosclerosis agents, methods for their use and pharmaceutical compositions containing them.

Growing community of inventors

East Lyme, CT, United States of America

David A Clark