Gensia, Inc.

Metabasis Therapeutics, Inc.

David A Bullough

Harry E Gruber

Bheemarao G Ugarkar

Clinton E Browne

Mark D Erion

Angelo J Castellino

Kevin M Mullane

Gary S Firestein

Leonard P Miller

Ernest K Metzker

Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various conditions which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.

Adenosine kinase inhibitors

Analogs of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) are provided which are useful in increasing extracellular levels of adenosine.

AICA riboside analogs

Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.

Methods for treating adenosine kinase related conditions

Growing community of inventors

San Diego, CA, United States of America

David A Bullough