Berry and Associates, Inc.

Warner-lambert Company

Other

Glen Research Corporation

Synaffix B.v.

David A Berry

Floris Louis Van Delft

Sander Sebastiaan Van Berkel

Luigi G Marzilli

James D Hoeschele

Anthony Denver Sercel

William H Pearson

Phillip D Cook

Hugh Mackie

Dean S Wise

Kee-Yong Jung

John B Randolph

Robert L Somers

John Cooke Hodges

Jorge Verkade

The specification discloses quenchers of excited state energy, probes and other conjugates comprising the same, and methods for their use. The quenchers of excited state energy have a structure comprising at least one reactive functional group for linking the quencher to a carrier molecule and at least three radicals covalently linked via exocyclic diazo bonds, the at least three radicals including at least one comprising a julolidine of the nominal formula: and the remainder of the at least three radicals being selected from the group of substituted and unsubstituted aryls, substituted and unsubstituted heteroaryls, and combinations thereof.

Dark quenchers, probes and other conjugates incorporating the same, and their use

A myo-inositol derivative: R, R, Rand Rare identical, being selected from POH, PONa, POK, POLi, POCa, POMg, PO(NH), PO(RNH), PO(RNH), PO(RN), PO(OR), H, COZ and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; Ris one of H, benzyl, 4-methoxybenzyl, COZ, POH, PONa, POK, POLi, POCa, POMg, PO(NH), PO(RNH), PO(RNH), PO(RN), PO(OR), and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; X is one of CH, CHCHO, and CHCHCHO; n is an integer from 1 to 8; Lis a single bond or CH; Lis one of a single bond, CONH, CHCONH, CHCHCONH, CHCHNHCO, CHCHNHCONH, CHCHNHCSNH, CHCHNHSO, CHCHCHNHCO, CHCHCHNHCONH, CHCHCHNHCSNH, CHCHCHNHSO, NHCO, NHCONH, NHCSNH, OCONH, CH, CHCH, CHCHO, CHCHS, CHCHNH, CHCHCH, CHCHCHO, CHCHCHS, CHCHCHNH, and NH&#x2014;SO; and Ris a UV-visible chromophore, a UV-chromophore, a fluorescent moiety, or a radiolabeled moiety.

Probe for measuring phytase activity

A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base pairing with naturally occurring nucleosides. The nucleosides including the fluorescent nitrogenous base have many uses including but not limited to use in probes, in the synthesis of nucleic acids, and in investigating nucleic acid interactions with other nucleic acids and/or with proteins.

Fluorescent nitrogenous base and nucleosides incorporating same

Square-planar four-coordinate complexes of cis-platinum (II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity against transplanted L1210 and P388 murine leukemia cell lines.

Aminoalkyl-substituted cycloalkylamine platinum (II) complexes

Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity against transplanted L1210 and P388 murine leukemia cell lines.

Aminoalkyl-substituted azetidine platinum(II) complexes

The aminoglycoside and aminoglycotide N.sup.4 -(2,3,5-tri-O-acetyl-.beta.-D-ribofuranosyl)pyrimido[4,5-d]pyrimidine-4,8- diamine and N.sup.4 -(5-O-phosphono-.beta.-D-ribofuranosyl-pyrimido[4,5-d]pyrimidine-4,8-diami ne exhibit antiviral activity as well as cytotoxic activity against the L1210 and mammary 16/C tumor cell lines. An improved method for their production involves the production of a sylilated intermediate and reaction of the intermediate with tetra-O-acetyl-.beta.-D-ribofuranose in the presence of the specific catalyst trimethylsilyltrifluoromethanesulfonate.

Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and

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Ann Arbor, MI, United States of America

David A Berry