Leland Stanford Junior University

Other

Spectros Corporation

Sextant Medical Corporation

Xenogen Corporation

Cellnumerate Corporation

Sexant Medical Corporation

David A Benaron

Pamela R Contag

Christopher H Contag

Ilian H Parachikov

Daniel S Goldberger

Boris Rubinsky

Robert S Smith

David E Goodman

Michael R Fierro

Yair Talmi

Marvin Hutt

A device () for determining the presence, absence, concentration, or count of rare cell or cell-like objects in a turbid fluid consisting of a light source () for illuminating a chamber () containing a solution including complexes of suspended cells or cell-like moieties () and an optically-active agent, and further including an imaging detector () and an output () for providing a determined or displayed result. Methods of enumeration are also disclosed.

Rapid, no-flow, whole-blood, and volumetric circulating cell counting system and method

Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

Non-invasive localization of a light-emitting conjugate in a mammal

The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a molecular switching mechanism to express a reporter gene upon interaction with target substances. The invention further relates to methods using such biodetectors for detecting and quantifying selected substances with high specificity and high sensitivity.

Biodetectors targeted to specific ligands

An implantable ischemia detection system in which a white LED () produces a continuous, visible, broadband light illuminating a target site (). Light backscattered by the target is collected by a sensor (), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (). Power is provided by an internal power source (). The entire implantable device is encapsulated by a biocompatible shell () to add long-term safety with regard to implantation.

Implantable tissue ischemia sensor

A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.

Optical imaging of induced signals in vivo under ambient light conditions

An improved hybrid connector for rapidly, reliably, and reversibly making mixed optical and electrical connections has a plug () with one or more centrally located fiber-containing optical ferrules () and one or more peripheral electrical contacts (), and second, a socket () with interior electrical contacts () and a fiber-bearing central floating optical connector (). Insertion and rotation of a shaft () of the plug into a bore () of the socket connects the respective electrical contacts of the shaft and socket, and nearly-simultaneously couples the respective optical fibers of the plug ferrule and socket connector, thus creating a rapid, reversible, and low-cost hybrid connection optimized for both the electrical and optical requirements of a mixed optical and electrical connection.

Optical and electrical hybrid connector

An improved illuminator for generating broadband light, and for delivering the light to a sample with an improved delivery efficiency, for higher optical density and/or reduced thermal transfer, than achieved with conventional halogen bulb sources. The illuminator enables spectroscopic analysis in thermally-sensitive or spatially-constrained environments. A phosphor-coated broadband white LED and integrated collimating optics produces a continuous, collimated broadband light beam from 400 nm to 700 nm, which is then transmitted through space to a sample region, such as a living tissue in vivo. A method and system for measuring oxigeneration of mucosal or subsurface tissue is also described.

Spectroscopy illuminator with improved delivery efficiency for high optical density and reduced thermal load

Methods an compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease state are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

Growing community of inventors

Portola Valley, CA, United States of America

David A Benaron