The University of Texas System

Dispersol Technologies, LLC

Austinpx, LLC

Other

Integrico Composites, Inc.

Dave A Miller

Robert O Williams, Iii

James William McGinity

Chris Brough

James C DiNunzio

Justin M Keen

Sandra U Kucera

James C Dinunzio

Iii Williams Robert O

Jason T McConville

Ron Larabie

Sandra U Schilling

James W Mcginity

Robert O Williams

Jason T Mcconville

Robert O Iii Williams

Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.

Thermo-kinetic mixing for pharmaceutical applications

The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.

Formulations of deferasirox and methods of making the same

A system and method for aircraft passenger seating allows traditional passenger seats, which have fixed configurations, to meet new specifications. A bottom frame and backrest frame from a traditional passenger seat is used to form a new passenger seat. Features, such as improved cushioning, telescopic or fixed headrests, rotatable or fixed footrests and improve armrest assemblies may be added as part of the new passenger seat.

System and method for aircraft passenger seating

Aircraft passenger seat

A hot-melt extruded composition having finely divided drug-containing particles dispersed within a polymeric and/or lipophyllic carrier matrix is provided. The carrier softens or melts during hot-melt extrusion but it does not dissolve the drug-containing particles during extrusion. As a result, a majority or at least 90% wt. of the drug-containing particles in the extrudate are deaggregated during extrusion into essentially primary crystalline and/or amorphous particles. PEO is a suitable carrier material for drugs insoluble in the solid state in this carrier. Various functional excipients can be included in the carrier system to stabilize the particle size and physical state of the drug substance in either a crystalline and/or amorphous state. The carrier system is comprised of at least one thermal binder, and may also contain various functional excipients, such as: super-disintegrants, antioxidants, surfactants, wetting agents, stabilizing agents, retardants, or similar functional excipients. A hydrophilic polymer, such as hydroxypropyl methylcellulose (HPMC E15), polyvinyl alcohol (PVA), or poloxamer, and/or a surfactant, such as sodium lauryl sulfate (SLS), can be included in the composition. A process for preparing the extrudate is conducted at a temperature approximating or above the softening or melting temperature of the matrix and below the point of solubilization of drug-containing particles in the carrier system, and below the recrystallization point in the case of amorphous fine drug particles.

Stabilized HME composition with small drug particles

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Round Rock, TX, United States of America

Dave A Miller