Lupin, Inc.

Dattatray Karche Amit

Rajender Kumar Kamboj

Kamlesh Jyotindra Padiya

Bhavani Shankar Rajesh

Kumar Ram Naik

Barve Sitaram Rambhau

Kamalakannan Prabakaran

Ganpati Powar Rajendra

Subhash Ingawale Sachin

Shankar Dange Santoshkumar

This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

Methods, processes and intermediates for preparing chroman compounds

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Pune Maharashtra, India

Dattatray Karche Amit