Novartis Ag

Lifesensors, Inc.

Progenra, Inc.

Dattananda Chelur

Brian Walter Granda

Connie Hong

Steven J Orcutt

Craig Leach

Raymond J Peroutka

James Strickler

Yilin Yan

Kathryn Longenecker

Michael Eddins

Regis Cebe

Haihui Lu

Barbara Brannetti

Amy Rayo

Sunyoung Jang

The present disclosure provides CD19 binding molecules that specifically bind to CD19, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD19 binding molecules, and pharmaceutical compositions comprising the CD19 binding molecules and the conjugates. The disclosure further provides methods of using the C19 binding molecules to treat diseases and disorders associated with expression of CD19. The disclosure yet further provides recombinant host cells engineered to express the CD19 binding molecules and methods of producing the CD19 binding molecules by culturing the host cells under conditions in which the CD19 binding molecules are expressed.

CD19 binding molecules and uses thereof

The present disclosure provides CD2 binding molecules that specifically bind to CD2, including monospecific, bispecific and trispecific binding molecules, conjugates comprising the CD2 binding molecules, and pharmaceutical compositions comprising the CD2 binding molecules and the conjugates. The disclosure further provides methods of using the CD2 binding molecules to modulate CD2 signaling in order to treat a variety of immune (e.g., autoimmune), inflammatory and proliferative disorders. The disclosure yet further provides recombinant host cells engineered to express the CD2 binding molecules and methods of producing the CD2 binding molecules by culturing the host cells under conditions in which the CD2 binding molecules are expressed.

Variant CD58 domains and uses thereof

Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed.

Di- and poly-ubiquitin deubiquitinase substrates and uses thereof

Growing community of inventors

Chesterbrook, PA, United States of America

Dattananda Chelur