Cytoscan Sciences LLC

University of Washington

Other

Neurotherapeutics Pharma, Inc.

Neuropro Therapeutics, Inc.

Daryl W Hochman

Michael M Haglund

John Joseph Partridge

The present invention provides bumetanide analogs and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these bumetanide analogs and methods for their use. These analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the NaKClco-transporter or GABAreceptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, autism, bipolar disorder, cancer, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma. Huntington's Disease, insomnia, ischemia, migraine, migraine with aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, personality disorders, postherpetic neuralgia, psychosis, schizophrenia, seizure disorders, tinnitus, and withdrawal syndromes.

Bumetanide analogs, compositions and methods of use

The present invention relates to methods and compositions for treating neuropathic pain and neuropsychiatric disorders by administering agents that are effective in reducing the effective amount, inactivating, and/or inhibiting the activity of a Na&#x2014;K-2Cl(NKCC) cotransporter. In certain embodiments, the Na&#x2014;K-2Clco-transporter is NKCC1.

Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders

Methods and compositions for the treatment of neuropsychiatric disorders

The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neurophsyciatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and/or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Electrolyte cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed. The present invention also relates to methods and compositions for treating pain by administering ion-dependent cotransporter antagonists. Methods and compositions for enhancing cortical function, for example, in centers of cognition, learning and memory, by administering ion-dependent cotransporter agonists are disclosed.

Method of treating migraine headache without aura

Optical detection techniques for the assessment of the physiological state, health and/or viability of biological materials are provided. Biological materials which may be examined using such techniques include cells, tissues, organs and subcellular components. The inventive techniques may be employed in high throughput screening of potential diagnostic and/or therapeutic agents.

Method for identifying optical contrast enhancing agents

The present invention provides methods and systems for determining the presence and location of abnormal or pathological tissue, for identifying and mapping the margins of abnormal tissue, such as tumor tissue during surgical or diagnostic procedures, and for grading and characterizing tumor tissue by detecting changes in the optical properties of spatially defined areas of an area of interest following administration of a contrast enhancing agent.

Methods and systems for detecting abnormal tissue using spectroscopic techniques

Methods and systems for assessing biological materials using optical and spectroscopic detection techniques

The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one aspect of the present invention relates to methods and materials for treating seizure and seizure disorders, epilepsy, status epilepticus, migraine, spreading depression, intracranial hypertension; for treating the pathophysiological effects of head trauma, stroke, ischemia and hypoxia; for treating or protecting from the pathophysiological effects of neurotoxic agents such as ethanol; and for treating neurophsyciatric disorders and central nervous system edema by administering agents that modulate ionic concentrations and/or ionic gradients in the brain, particularly ion-dependent or cation-chloride cotransporter antagonists. Ion-dependent cotransport antagonists and combinations of such compositions with other agents for treating various conditions are disclosed. The present invention also relates to methods and compositions for treating pain by administering ion-dependent cotransporter antagonists. Methods and compositions for enhancing cortical function, for example, in centers of cognition, learning and memory, by administering ion-dependent cotransporter agonists are disclosed. Methods and systems for screening drug candidate compounds for desired activities using in vitro and in vivo systems are disclosed.

Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms

The present invention provides a method for determining the presence of solid tumor tissue, for identifying and mapping the margins of solid tumors during surgical or diagnostic procedures, and for grading and characterizing tumor tissue by detecting changes in the optical properties of an area of interest suspected to contain tumor tissue.

Method and apparatus for optically imaging solid tumor tissue

The present invention provides a method and apparatus for distinguishing neuronal tissue from surrounding tissue, for distinguishing functional neuronal tissue from dysfunctional tissue, and for imaging of functional neuronal areas in cerebral cortex by detecting changes in the optical properties of the neuronal tissue following stimulation of neuronal activity.

Methods and apparatus for optically imaging neuronal tissue and activity

There is disclosed an apparatus for real-time imaging of cortical intrinsic signals or imaging tumor tissue or the margins, dimensions and grade of tumor tissue, comprising, a means for obtaining analog video images and a means for processing the analog video signals into either an averaged control frame or a subsequent frame, a means for acquiring and analyzing a plurality of subsequent frames and averaged control frame to provide a difference image, wherein the difference image is processed to account for movement and noise and amplify the changes across a dynamic range of the apparatus, and a means for displaying the difference image alone or superimposed over an analog video image. The present invention further provides a method for imaging margins, grade and dimensions of solid tumor tissue located in an area of interest, comprising illuminating the area of interest with high intensity, emr (electromagnetic radiation) containing the wavelength of emr absorbed by a dye, obtaining a video signal of the area of interest as an averaged control image and processing the averaged control image into the averaged control frame, administering the dye by bolus injection into a vein circulating to the area of interest, obtaining a series of video images of the area of interest over time as subsequent images and processing each subsequent image as a subsequent frame, comparing each subsequent frame with the processed averaged control frame to obtain a series of difference images, and comparing each difference image for initial evidence of changed absorption within the area of interest which is the outline of solid tumor tissue, whereby tumor tissue is characterized by faster absorption of emr as a result of increased vascularity of solid tumor tissue and inability to clear the dye as fast as normal tissue. The present invention further comprises a method for optically imaging functional and dysfunctional areas of interest of the cortex in an awake or anesthetized patient comprising illuminating the area of interest with high intensity emr containing the near-infrared wavelengths of emr, obtaining a video signal of the area of interest as an averaged control image and processing the averaged control image as an averaged control frame, administering a paradigm to the patient to stimulate an intrinsic signal, obtaining a series of video signals of the area of interest over time as subsequent images and processing each subsequent image into a subsequent frame, comparing each subsequent frame with the processed averaged control frame to obtain a series of difference images, and comparing each difference image for initial evidence of an intrinsic signal within the area of interest, whereby an intrinsic signal is characterized by a change in reflectance properties manifest as a signal in the difference image.

Optical imaging methods

Methods and systems for assessing biological materials using optical

There is disclosed a method for screening drug candidate compounds for anti-epileptic activity, a method for screening drug candidate compounds for activity to prevent or treat symptoms of Alzheimer's disease, and a method for determining cell viability and health of living cells inside polymeric tissue implants.

Growing community of inventors

Bahama, NC, United States of America

Daryl W Hochman