Med-el Elektromedizinische Geraete Gmbh

Darshan Shah

Dirk Meister

Carolyn Garnham

Patrick Hübner

Optogenetic signal processing is described for an auditory prosthesis with an intracochlear array of optical stimulation sources implanted in a patient having auditory neurons genetically modified with light sensitive ion channels. Stimulation timing signals are generated for the corresponding auditory neurons for each band pass signal based on characteristic temporal fine structure features of the band pass signals. The stimulation timing signals include: i. one or more channel opening signals adapted to open the ion channels of the corresponding auditory neurons, and ii. one or more channel closing signals adapted to close the ion channels of the corresponding ion channels. Optical stimulation signals are then produced for the optical stimulation sources based on the stimulation timing signals.

Multichannel optogenetic stimulation and inhibition

A signal processing arrangement generates optical stimulation signals to optical stimulation contacts in an implanted cochlear implant array. An input sound signal is transformed into band pass signals that each represent an associated band of audio frequencies, with each band pass signal includes an envelope component characterizing loudness of the band pass signal, and a fine structure component characterizing temporal details of the band pass signal. One or more of the signal components of each band pass signal is half wave rectified to remove negative phase signals. Signal slope is determined that corresponds to rate of change of the rectified one or more signal components. Then constant-rate optical stimulation pulses are generated for one or more given band signals only when the rectified one or more signal components has a positive signal slope.

Multichannel opto-mechanical stimulation

Arrangements are described for fitting a cochlear implant to a recipient patient. An acoustic stimulus is delivered to an ear of the patient over a range of acoustic frequencies. A baseline acoustic transfer function resulting from the acoustic stimulus is measured using a response sensor configured to sense pressure response characteristics in the middle ear. And a maximum comfortable level (MCL) of stimulation is determined for at least one stimulation contact in the electrode array, based on performing an electrically evoked measurement to an electric stimulation signal and using the response sensor to measure a modified acoustic transfer function. The modified acoustic transfer function is compared to the baseline acoustic transfer function to determine when a stapedius reflex response occurs and identify the MCL.

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Innsbruck, Austria

Darshan Shah