Galderma Research & Development Snc

Metabasis Therapeutics, Inc.

Structural Bioinformatics Inc.

Roswell Biotechnologies, Inc.

Darryl Rideout

Ruth F Nutt

Joseph Edward Semple

Barry L Merriman

Zacharia S Cheruvallath

Paul Mola

Magnus Pfahl

Tim Geiser

Xian-Ping Lu

Hongyue Zhang

Jing Wang

Venkatachalapathi Yalamoori

Hengyi Zhu

Kalyanaraman Ramnarayan

Jason J Sun

Mark Shenderovich

Shankari Mylvaganam

Jian Hua Zheng

Jianzhong Sun

Christina Niemeyer

Colin J Loweth

Feiyue Wu

Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

Thiazole and thiadiazole inhibitors of tyrosine phosphatases

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and/or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-&lsqb;3-(1-adamantyl)-4-methoxyphenyl&rsqb;-2-naphthoicacid, 2-&lsqb;3-(1-adamantyl)-4-methoxyphenyl&rsqb;-5-benzimidazole carboxylic acid, and 6-&lsqb;3-(1-adamantyl)-4,5-methylenedioxyphenyl&rsqb;-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and/or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-&lsqb;3-(1-adamantyl)-4-methoxyphenyl&rsqb;-2-naphthoic acid, 2-&lsqb;3-(1-adamantyl)-4-methoxyphenyl&rsqb;-5-benzimidazole carboxylic acid, and 6-&lsqb;3-(1-adamantyl)-4,5-methylenedioxyphenyl&rsqb;-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

Methods and compositions that act as specific inhibitors of ALF activity for the prophylaxis and treatment of anthrax infections.

Inhibitors of anthrax lethal factor activity

Apoptosis inducing adamantyl derivatives and their usage as anti-cancer

Growing community of inventors

San Diego, CA, United States of America

Darryl Rideout