Boehringer Ingelheim International Gmbh

Biota Scientific Management Pty Ltd

Darryl McConnell

Keith G Watson

Guy Y Krippner

Pauline Stanislawski

Maria Impagnatiello

Tobias Wunberg

Ulrike Weyer-Czernilofsky

Lars Van Der Veen

Matthias Grauert

Steffen Steurer

Betty Jin

Wen-Yang Wu

Dirk Kessler

Bodo Betzemeier

Siegfried Schneider

Thomas Gerstberger

Matthias Hoffmann

Harald Engelhardt

Andreas Schoop

Christiane Kofink

Simon J F MacDonald

Stephen E Shanahan

Ralph Brueckner

Van T T Nguyen

Christoph Hoenke

Stefan Scheuerer

Martin Steegmaier

Steffen Breitfelder

Trixi Brandl

Frank Hilberg

Udo Maier

Irene Waizenegger

Bernd Krist

Oliver Kraemer

Christian Klein

Andreas Zoephel

Michael Gmachl

Norbert Schweifer

Oliver Simon

Charlotte Reither

Michael D Dowle

Heinz Stadtmueller

Daniel Kuhn

Guido Boehmelt

Andrew McM Mason

This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as novel intermediates useful in the preparation of the compounds of formula I.

Antiviral agents

The present invention encompasses compounds of general formula (1) wherein Rto Rand X are defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties. 

Thia-triaza-indacenes

The present invention encompasses compounds of general Formula (1) wherein Rto Rare defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties. 

5-alkynyl-pyrimidines

The present invention encompasses compounds of general formula (1), wherein the groups Rto R, Q, Q, L, n and m are defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations containing such compounds and their use as medicaments. 

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The present invention encompasses compounds of general formula (1) wherein Rto R, A, X, m and k are defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties. 

Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (P13-kinases) inhibitor

The present invention encompasses compounds of general formula (1) while the groups Rto Rand the units W, L, Qand Qare defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use as medicaments having the above-mentioned properties. 

Pyridons as PDK1 inhibitors

The present invention encompasses compounds of general formula (1) wherein the groups Rto R, Q, Q, Q, L and n are defined as in claim, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

Chemical compounds

The present invention encompasses compounds of general formula (1) 

Thiazolyl-dihydro-indazoles

The present invention encompasses compounds of general formula (1) whereinRto Rand X are defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Thia-triaza-cyclopentazulenes

The present invention encompasses compounds of the general formula (1) in which

The present invention encompasses compounds of general formula (1) wherein

Thiazolyl-dihydro-indazole

The present invention encompasses compounds of general formula (1) whereinRto Rare defined as in claim, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

Growing community of inventors

Vienna, Austria

Darryl McConnell