Millipore Corporation

Darryl J Rappin

James M Coull

Alex Garfield Bonner

Michael J Steuck

Hubert Koester

Malcolm G Pluskal

A membrane suitable for immobilizing peptides and proteins is disclosed. The membrane is a flexible, polymeric, porous membrane which contains functional groups capable of covalently linking the peptides and proteins. The functional groups can be provided by reacting the membrane itself or a coating thereon with nucleophiles which provide --NH.sub.2, --SH, --OH or --COOH functionality to the membrane surface. Additionally, surfaces containing --NH.sub.2 groups can be further reacted with diisothiocyantes to provide an isothiocyanate functionality having enhanced covalent binding characteristics.

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North Billerica, MA, United States of America

Darryl J Rappin