Scripps Health

Integrated Shoulder Collaboration, Inc.

Xpandortho, Inc.

Advanced Mechanical Technology, Inc.

Active4d, Inc.

Other

The Scripps Research Institute

Flex Partners, Inc.

Consortium of Focused Orthopedists, LLC

Scipps Health

Darryl David D'Lima

Clifford W Colwell

Tsaiwei Olee

David G Matsuura

Armodios M Hatzidakis

Drew Miller

Heinz R Hoenecke, Jr

James D Kelly, Ii

Nathaniel E Skinner

Scott R Jacobson

Philip Simpson

Bruce F White

Heinz Hoenecke

Shawn Patrick Grogan

Sungho Jin

Daniel Kincade

Martin Lotz

Clifford W Colwell, Jr

Jihye Baek

Shawn Grogan

Jr Md Clifford W Colwell

Heinz R Hoenecke Jr

James D Kelly Ii

An implant for shoulder arthroplasty includes a stem and optionally a head component or a cup component. The stem is sized and shaped to fit into an intramedullary canal of the humerus. The proximal portion of the stem has a concave taper and the distal portion of the stem has a taper. The distal taper includes an anterior-posterior taper and a medial-lateral taper. The shape of the stem loads the metaphysis of the humerus with a greater load than the load applied to the diaphysis of the humerus.

Shoulder arthroplasty implant system

A joint replacement balancing system which provides real-time feedback to a surgeon during a joint replacement surgery to assist the surgeon to balance a joint replacement. The joint replacement balancing system includes a non-transitory processor-readable medium storing code representing instructions to cause a processor to receive a signal from a joint balancing apparatus, determine if the joint replacement is out of balance, determine a corrective course of action to bring the joint into balance and generate and display to the surgeon during the joint replacement surgery a recommended corrective course of action to complete the joint replacement surgery.

Apparatus and methods for balancing a joint

A system and method is used to monitor, control, and/or provide feedback relative to one or more factors related to a patient's body, such as a shoulder, pursuant to a treatment process. The system monitors, controls, and/or provides feedback relative to shoulder factors including shoulder motion, shoulder muscle contraction, and external pressure on the shoulder.

Shoulder monitoring and treatment system

Disclosed herein are methods of producing chondrocytes from pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Methods of differentiating stem cells into chondrocytes

Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.

Electrospinning of cartilage and meniscus matrix polymers

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Systems and methods to repair tissue defects

Methods of printing a bio-ink on a substrate are provided comprising at least one bio ink layer, said method comprising: i) positioning a printhead comprising a two-dimensional array of print nozzles within proximity of or in contact with a substrate; and ii) ejecting a bio-ink through the print nozzles onto the substrate, forming a bio ink layer, wherein the bio-ink construct comprises at least one bio-ink layer. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.

Tissue array printing

A joint balancing insert with an actuated mechanism is for balancing a joint during a joint surgery is disclosed. The joint balancing insert includes a first plate, a second plate and an actuator there between. The second plate includes an integrated mounting portion for mounting a cutting block used to guide surgical cuts of the joint during the joint surgery. Various configurations of the integrated mounting portion may be implemented in the insert to provide for mounting various types of cutting blocks, such as cutting blocks for tibial cuts, femoral cuts, and distal femoral cuts.

Balancing device for arthroplasty and methods for use

Disclosed herein are systems, devices and methods for processing tissue, such as autologous tissue. Implementations of a Stromal Vascular Fraction (SVF) system are described that can isolate and wash harvested cells contained within various tissues, such as isolate and wash stem cells from fat tissue. The SVF system can minimize the handling and transferring of tissue and fluids, including minimizing the number of human interventions and manipulations required throughout processing. The SVF system can ensure sterility of processed tissue and harvested cells, as well as significantly reduce cost and time associated with the processing.

Stromal vascular fraction processing devices and methods

Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Method of making a population of chondrocytes from reprogrammed chondrocytes

Growing community of inventors

San Diego, CA, United States of America

Darryl David D'Lima