Scripps Health

Xpandortho, Inc.

Darryl D D'lima

David G Matsuura

Clifford W Colwell

Tsaiwei Olee

Philip J Simpson

Clifford W Colwell, Jr

Jr Clifford W Colwell

Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

Systems and methods to repair tissue defects

Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

Methods of reprogramming chondrocytes

Growing community of inventors

San Diego, CA, United States of America

Darryl D D'lima