Tonix Pharmaceuticals Holding Corp.

Tonix Pharmaceuticals Inc.

Center for Neurologic Study

Pharmocon LLC

Darryl C Rideout

Seth Lederman

Greg Sullivan

Andrew Mamoru Kawasaki

James P Demers

Richard Alan Smith

John F O'Connell, Jr

Kathleen Myers

Philip S Schein

The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

Analogs of cyclobenzaprine and amitryptilene

The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. The compounds of this disclosure also relate to The use of these compounds as radio&#x2014; and chemo&#x2014;protectors is also described.

Radio-protective and chemo-protective substituted thiols

Substituted analogs of dextromethorphan (DM) are disclosed, which are shown to have substantial binding affinity at both NMDA and sigma-1 receptors, and which are degraded by human liver enzymes more slowly than dextromethorphan. The analogs are useful as alternatives to dextromethorphan, and can provide the same benefits without requiring co-administration of a cytochrome P-450 enzyme inhibitor.

Analogs of dextromethorphan with balanced receptor activities

Analogs of cyclobenzaprine and amitriptyline

The invention provides buffers stable to oxidants, including chlorine and hypochlorous acid, which are usable in the pH range 3-7. The invention also provides stable, buffered solutions comprising hypochlorous acid, having a pH between 3 and 7, and disposable wiping articles impregnated with these solutions.

Materials amd methods for buffering active chlorine solutions

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Milford, PA, United States of America

Darryl C Rideout