California Institute of Technology

Darron K Young

Yu-Chong Tai

Jun Xie

Po-Jui Chen

Chi-Yuan Shih

Michael Roukes

Edward B Myers

Jessica L Arlett

Mo Li

Benjamin Gudlewski

Igor Bargatin

Hong X Tang

Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple separation columns integrated into a single substrate. Using such a device, parallel analysis of multiple samples can be performed simultaneously and/or sequential analysis of a single sample can be performed simultaneously on a single chip or substrate. The devices and systems are well suited for use in high pressure liquid chromatography (HPLC) applications. HPLC chips and devices including embedded parylene channels can be fabricated using a single mask process.

Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same

A system containing a micro-mechanical or nano-mechanical device and a method of operating the same is provided. The device includes a resonator and a piezoresistive element connected to the resonator. The method includes AC biasing the piezoresistive element at a first frequency, driving the resonator at a second frequency different from the first frequency, and detecting a mechanical response of the resonator at one or both of a difference frequency and a sum frequency of the first and second frequencies.

Detection of resonator motion using piezoresistive signal downmixing

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South Pasadena, CA, United States of America

Darron K Young