University of Delaware

Darrin J Pochan

Joel Patrick Schneider

Norman Joseph Wagner

Bulent Ozbas

Daphne A Salick

Joel P Schneidér

Karthikan Rajagopal

Juliana Kretsinger

Monica C Branco

Lisa Ann Butterick

A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37&#xb0; C. with a pH=7.4 BTP buffer containing 150 mM NaCl.

Macromolecular diffusion and release from self-assembled &#x3b2;-hairpin peptide hydrogels

A peptide comprising the sequence VKVKVRVKVPPTKVKVRVKV-NHforms a hydrogel which has the ability to shear-thin and recover. The hydrogel, both before and after shear-thinning, is capable of killing bacteria, including methicillin-resistant(MRSA).

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The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution. Such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristic of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

Hydrogels and uses thereof

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Landenberg, PA, United States of America

Darrin J Pochan