Corixa Corporation

Hdt Bio Corp.

Infectious Disease Research Institute

Tti Ellebeau, Inc.

Access To Advanced Health Institute

University Medical Pharmaceuticals Corp.

University of Washington

University of Virginia Patent Foundation

Catura Corporation

Compliment Corporation

Corxia Corporation

Darrick Carter

Steven G Reed

Thomas S Vedvick

Gary R Fanger

Marc W Retter

Amit Praful Khandhar

Malcolm Duthie

Jesse Erasmus

Bryan J Berube

Jennifer L Mitcham

Michael D Kalos

Aijun Wang

Robert A Henderson

Davin C Dillon

Jiangchun Xu

Yasir A W Skeiky

Susan L Harlocker

Yuqiu Jiang

John A Stolk

Samuel X Li

Craig H Day

William T Hepler

Tongtong Wang

Chaitanya S Bangur

Michael J Lodes

Liqun Fan

Jane Mannion

Yoshihiro Watanabe

Patricia Dianne McNeill

Raymond L Houghton

Christopher B Fox

Teresa M Foy

Carlota Vinals Y De Bassols

Neal Van Hoeven

Susan S Lin

Jacob Freeman Archer

Madeleine Joy Meagher

Margarita Durham

Andria McNabb

Mayuresh M Abhyankar

Jeffrey C Johnson

Joshua King Hoyt

Forrest Scott Seitz

Ronald Jay Berenson

James Thorne

Paul R Sleath

Steven P Fling

Andre Lieber

William A Petri

Josh Hoyt

Jim Thorne

Lars Peter Aksel Berglund

John Hural

Gordon E King

Paul Algate

Hongjie Wang

Glenn Godden

Gregory A Smith

André Lieber

Ta Deng

Raymond J Francis

John Trengrove

Gregory Hunt

Ray Francis

John Trengove

Greg Hunt

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

Compositions and methods for delivery of RNA

The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

RNA vaccines against infectious diseases

Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.

Pegylated liposomes and methods of use

The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

SARS-CoV-2 RNA vaccine compositions and methods of use

Provided herein are dried compositions and methods for preparing such compositions for use in delivery of a nucleic acid to a subject. The dried composition may comprise a lipid carrier, wherein the lipid carrier is a nanoemulsion comprising a hydrophobic core, optionally one or more inorganic nanoparticles and one or more lipids, one or more nucleic acid, and at least one cryoprotectant. Methods of using these dried compositions for treatment are also provided.

Dried nanoparticle compositions

Nucleic acid-small diameter and liquid core nanoparticle complexed compositions

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. Compositions of the disclosure include nucleic-acid lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen. The nanoemulsion compositions of the disclosure comprises a hydrophobic core, optionally including inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided, including methods for administering to a subject a composition of the disclosure in an amount sufficient to generate an immune response.

Compositions and methods for delivery of nucleic acid-lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen

Growing community of inventors

Seattle, WA, United States of America

Darrick Carter