Children's Medical Center Corporation

Harvard College

Dana-farber-cancer Institute Inc.

Darren Yang

Wesley Philip Wong

Andrew Ward

Clinton H Hansen

William M Shih

Kenneth Anders Halvorsen

Bhavik Nathwani

Eric M Mulhall

Hongyu Zhao

Johanna Blass

This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.

Nucleic acid nanoswitch construction methods

Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

Rapid and sensitive detection and quantification of analytes in complex samples using polymer-based methods

An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Spinning apparatus for measurement of characteristics relating to molecules

Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.

Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids

Holder

Growing community of inventors

Somerville, MA, United States of America

Darren Yang