Boston University

Darren Roblyer

Alyssa Torjesen

Yanyu Zhao

An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane.

Systems and methods for measuring water and lipid content in tissue samples

A tissue oximetry system employing diffuse optical spectroscopy includes an optical subsystem and an electronics and processing subsystem, together generating modulated optical signals processing a response optical signal in order to obtain measurements of blood oxygen values for a tissue from per-wavelength absorption values. Signal sources generate RF modulation signals, and ADC circuitry generates streams of digital sample values from analog detection signals. Data acquisition circuitry and a processor (1) provide RF modulation command values in synchronism with sampling operation according to an offset pattern and rate, stepping through an RF range to obtain measurements of the absorption values in measurement intervals at least 10 times per second, (2) in each of the measurement intervals, calculate the model to obtain the blood oxygen values from the measurements of the absorption values, and display or otherwise use the obtained blood oxygen values in higher-level diagnostic assessment of tissue blood oxygenation.

Growing community of inventors

Jamaica Plain, MA, United States of America

Darren Roblyer