Zoll Circulation, Incorporated

Backbeat Medical, Inc.

Revivant Corporation

Caliber Therapeutics, Inc.

Cordis Neurovascular, Inc.

Cardiac Pathways Corporation

Freehold Surgical, Inc.

Codman & Shurtleff, Inc.

Emergency Medical Systems, Inc.

Cordis Corporation

Zoll Medical Corporation

Corris Neurovascular, Inc.

Smith, Jeffrey

Sherman, Darren R.

Darren R Sherman

Kenneth H Mollenauer

Yuval Mika

Daniel Burkhoff

Robert S Schwartz

Robert A Van Tassel

Steven R Bystrom

Robert Burgermeister

James Adam Palazzolo

William R Baumbach

Donald K Jones

Henry R Halperin

Ronald David Berger

Cameron Shea Miner

Mark L Pomeranz

Jeffrey Smith

Troy J Chapman

Juan A Lorenzo

Vladimir Mitelberg

Gregory Walter Hall

Paul Quentin Escudero

Bob H Katz

James O Jensen

Mir A Imran

Robert R Slazas

John H Thinnes, Jr

Keith Balgobin

Hiep Quang Do

Richard Champion Davis, Iii

John H Thinnes

Frederick Feller

N Parker Willis

Yufu Li

Chunlin Yang

Murty Narayan Vyakarnam

Iksoo Chun

Steven C Anderson

Amanda E Jordan

Peter Park

Stephen West

Dale Rieb

Robert B West

Scott Tedder

Matthew Gounis

James A Palazzolo

Frederick Iii Feller

Hiep Do

Richard Champion Davis Iii

Fredrick Iii Feller

Iii Frederick Feller

Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

Methods and systems for lowering blood pressure through reduction of ventricle filling

Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

Methods and systems for controlling blood pressure by controlling atrial pressure

Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for stent deployment, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

Balloon catheter systems for delivery of dry drug delivery vesicles to a vessel in the body

Systems and methods for controlling blood pressure via electrical stimulation of the heart are disclosed. Embodiments may include at least two different stimulation patterns, each configured to reduce blood pressure to a different degree, and may alternate between stimulation patterns based on the need of a patient, for example, alternating between day and night or between periods of strenuous and light activity. Some embodiments may take advantage of a slow baroreflex response that occurs after treatment is stopped, suspending treatment for extended periods, and then resuming treatment before blood pressure levels reach pretreatment values. Embodiments may control blood pressure by controlling atrial pressure and atrial stretch.

Methods and systems for controlling blood pressure

A specimen retrieval system for easier tissue removal during endoscopic surgery. The device includes a specimen tube with a main tube, and a mechanism for pulling and everting the distal end of the tube into the tube, or a side channel provided within the tube. The mechanism may include a tether fixed to the distal edge of the tube, or a grasper operable to grasp the distal edge of the tube.

Specimen retrieval system for use in endoscopic surgery

An apparatus and its method of use in delivering surgical tissue connectors into an area of the body and removing the surgical tissue connectors from the body area. The tissue connectors are connected to a base which allows for easy adjustment of the tissue connectors along a cord. The base includes a locking mechanism which impinges a sliding knot in the cord, and, in alternate configurations of the locking mechanism and knot, impinges on the sliding knot to prevent sliding in a loosening direction but allow sliding in a tightening direction, or allows sliding in a loosening direction.

Apparatus and method for delivering surgical tissue connectors into an abdominal cavity and removing the surgical tissue connectors from the abdominal cavity

Methods and systems for treating cardiac malfunction are disclosed, which according to an embodiment, may involve delivering a stimulation pattern of stimulation pulses to at least one cardiac chamber of a heart, with at least one of the stimulation pulses having a first stimulation setting configured to reduce at least one of end systolic volume (ESV) and end diastolic volume (EDV) in the heart and at least one of the stimulation pulses having a second stimulation setting different from the first stimulation setting, and with the stimulation pattern being configured to reduce the at least one of end systolic volume (ESV) and end diastolic volume (EDV) by at least 5% and maintain the at least one of end systolic volume (ESV) and end diastolic volume (EDV) on average at such reduced volume for a time period of at least one hour.

Methods and systems for treating cardiac malfunction

Systems and methods for reducing ventricle filling volume are disclosed. In some embodiments, a stimulation circuit may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated at a consistent rate to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, a stimulation circuit may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

A specimen retrieval system for easier tissue removal during endoscopic surgery. The devices include a specimen tube with a main tube, and a mechanism for pulling and everting the distal end of the tube into the tube, or a side channel provided within the tube. The mechanism may include a tether fixed to the distal edge of the tube, or a grasper operable to grasp the distal edge of the tube.

Growing community of inventors

Sunnyvale, CA, United States of America

Darren R Sherman