Other

Biogen Idec Ma Inc.

Curis, Inc.

Biogen Idec, Inc.

Biogen Ma Inc.

Darren P Baker

R Blake Pepinsky

Russell Colyn Petter

Ellen A Garber

Frederick Robbins Taylor

Jeffrey A Porter

Kevin P Williams

Dingyi Wen

Alphonse Galdes

Edward Y Lin

Donna M Hess

Ling Ling Chen

KoChung Lin

Lance L Hood

Paul H Weinreb

Kathryn Strauch

Chenhui Zeng

Kochung Lin

Ingrid BJK Joseph

The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.

Polyalkylene polymer compounds and uses thereof

Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

Hydrophobically-modified protein compositions and methods

Hydrophobically-modified hedgehog protein compositions and methods

Duckling floating dispenser

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Hingham, MA, United States of America

Darren P Baker