Glaxo Group Limited

Glaxosmithkline LLC

Darren Jason Mitchell

Mervyn Thompson

Susan Marie Westaway

Jonathan Thomas Seal

Gregor James MacDonald

Emmanuel Hubert Demont

Dominique Amans

Harshad Kantilal Rami

Geoffrey Stemp

Robert J Watson

Leontine Saskia Trouw

Samantha Louisa Brown

Tetrahydroquinoline derivatives, pharmaceutical compositions containing such compounds and to their use in therapy.

Tetrahydroquinoline derivatives useful as bromodomain inhibitors

Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy.

The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.

Compounds

The present invention relates to novel biaryl derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.

Biaryl compounds useful as agonists of the Gpr38 receptor

Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. 

Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases

Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, P, X, Y, q, r ans s are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds in medicine.

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Harlow, United Kingdom

Darren Jason Mitchell