Cancer Research Technology Limited

Astex Therapeutics Limited

Oxford University Innovation Ltd

Darren James Dixon

Steven Howard

Kim Louise Hirst

James Daniel Osborne

Jeffrey David St Denis

Brian Christopher Bishop

Jonas Calleja Priede

Matthew James Gaunt

Meenakshi Sundaram Shanmugham

David Parry-Jones

Aaron Michael Dumas

Charlotte Mary Griffiths-Jones

Jeremy Peter Scott

David Cousin

Rhian Sara Holvey

Benjamin David Cons

Steven Douglas Hiscock

Peter Richard Mullens

David John Nash

Alistair J Farley

Guillaume François Parra

Marta G Núñez

Nicholas Paul Richards

Isabelle Anne Lemasson

Alan Richard Burns

The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them

The present invention provides a bifunctional catalyst of the formula (1): wherein: each Ris independently selected from an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group and an optionally substituted alkaryl group; Z represents a divalent organic linking moiety optionally containing one or more stereocenters; and EWG represents an electron-withdrawing group.(R)P&#x2550;N&#x2014;Z&#x2014;NH-EWG&#x2003;&#x2003;(1)

Bifunctional organic catalysts

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Oxford, United Kingdom

Darren James Dixon