Allison Transmission, Inc.

Gm Global Technolgoy Operations, Inc.

Quest Diagnostics Investments, Inc.

Quest Diagnostics Investments Incoporated

Darren J Weber

Charles Francis Long

John William Edward Fuller

Nigel J Clarke

Stephen William Murray

John W E Fuller

Scott Goldman

Michael McPhaul

Jason Ellis

Diana Tran

Michael P Caufield

Jeffrey E Shultz

Phillip F McCauley

Thomas H Wilson

Scott E Mundy

Phillip F Mc Cauley

Travis A Brown

John William Fuller

Stephen Murray

John W Fuller

Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

Apolipoprotein e isotype detection by mass spectrometry

Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (Aβ42) to amyloid beta 40 (Aβ40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

Amyloid beta detection by mass spectrometry

Apolipoprotein E isotype detection by mass spectrometry

Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.

Methods for detecting chromogranin a by mass spectrometry

Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. In another aspect, provided herein are methods for determining the ratio of amyloid beta 42 (A&#x3b2;42) to amyloid beta 40 (A&#x3b2;40). In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.

An apparatus for multiplexing gear engagement control in an automatic transmission is provided. At least two friction engagement devices are configured to selectively engage and disengage a different gear ratio of the transmission. A trim system is configured to selectively supply engagement and disengagement pressures to at least one fluid passageway. A first control valve is fluidly coupled directly to the at least one fluid passageway and directly to each of the at least two friction engagement devices. The first control valve is configured to selectively route the engagement and disengagement pressures through the first control valve directly to the at least two friction devices.

System and method for multiplexing gear engagement control and providing fault protection in a toroidal traction drive automatic transmission

A fast valve actuation system for an automatic vehicle transmission includes a pair of spring-biased shift valves. Solenoids control the application of pressurized hydraulic fluid to the head of each of the shift valves. Each shift valve has at least one port that is coupled to a fluid chamber of a torque transferring mechanism of an automatic transmission. The position of each of the shift valves determines whether its ports are connected with fluid pressure. Fluid passages connect the head of each shift valve to the spring pocket of the other shift valve.

Fast valve actuation system for an automatic transmission

A transmission includes an electro-hydraulic controller that includes redundancy in the hydraulic circuit that permits single fault failures to be compensated for by changing the flow path of hydraulic fluid to bypass the single fault failure. The redundancy results in the ability of the transmission to maintain full operation in all modes.

Multi-plexing clutch logic control of a multi-mode transmission

Variator control with torque protection

An apparatus and method are disclosed for controlling fluid flow to a variator which responsive to separate high and low pressure fluids to control an output torque thereof. A first trim valve may be responsive to a first control signal to supply a first fluid at a fluid outlet thereof. A second trim valve may be responsive to a second control signal to supply a second fluid at a fluid outlet thereof. A variator switching sub-system may controllably supply the high pressure fluid and the low pressure fluid to the variator. A multiplex valve may be fluidly coupled to the outlets of the first and second trim valves, and may supply the first fluid as the high pressure fluid to the variator switching sub-system during at least one predefined operating condition and may otherwise supply the second fluid as the high pressure fluid to the variator switching sub-system.

Variator multiplex valve scheme for a torroidal traction drive transmission

An apparatus and method are disclosed for controlling fluid flow in a motor vehicle transmission. At least one friction engagement device is fluidly coupled to a first pump, and a lubrication and cooling sub-system is normally fluidly coupled to a second pump. Illustratively, when a flow rate of the fluid in the first fluid passageway is less than a threshold fluid flow rate, a temperature of the fluid is greater than a temperature threshold and a fluid flow demand is greater than a fluid flow demand threshold, fluid flow from the second pump to the lubrication and cooling sub-system is blocked and fluid supplied by the second pump is instead directed to the at least one friction engagement device such that fluid is supplied by both the first and second pumps only to the at least one friction engagement device.

Dual pump regulator system for a motor vehicle transmission

An apparatus for controlling a variator having at least one roller between two torroidal disks may include at least one actuator responsive to fluid pressure at separate high side and low side fluid inlets thereof to control torque applied by the at least one roller to the disks. First and second variator switching valves may each receive a first fluid at a first pressure and a second fluid at a second lesser pressure. The first and second variator switching valves supply the first fluid to the high side fluid inlet and the second fluid to the low side fluid inlet during two of four different operational states together defined by the variator switching valves, and supply the second fluid to the high side fluid inlet and the first fluid to the low side fluid inlet during each of the remaining two of the four different operational states.

Growing community of inventors

Indianapolis, IN, United States of America

Darren J Weber