Southwest Research Institute

Baker Hughes Corporation

Bernard Technologies, Inc.

Darren E Barlow

Albert M Zwiener

Stephen Thomas Wellinghoff

Joseph A McDonough

Joel J Kampa

Neal K Vail

Joseph T Persyn

Eliot Mark Slovin

Chel W Lew

Jeffrey Nelson Harris

Herman W Schlameus

Niraj Vasishtha

Mark R Heistand

Michael A Miller

Scott F Timmons

Sumner A Barenberg

Nagesh Sri Kommareddi

Jenny Finkbiner

James D Oxley

Ryan Dinius

A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disksand spacers () are stacked to form a disk stackhaving a feed wellin the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into spacer channels () within or on the surface of the spacers. The channels () communicate the fluid toward the outer edges of the disks. The disk surface past the spacers () can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Multi-disk spinning disk assembly for atomization and encapsulation

A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Multi-disk spinning disk assembly for atomization and encapsulation with spacing disks for adjusting exit gap

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates

The present disclosure relates to a microcapsule and a method of forming a microcapsule which may be used for oxygen sensitive materials. The microcapsule may comprise a shell encapsulating a core material having a surface, wherein the shell comprises a first organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges. This may then be followed by forming a first layer comprising an inorganic or organic polyelectrolyte on the microcapsule surface, where the polyelectrolyte of the first layer provides a plurality of cationic or anionic charges, opposite to the charge of the shell polyelectrolyte. This may then be followed by forming a second layer comprising a second organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges, opposite to the charge of the first layer polyelectrolyte.

Layer by layer modification of microcapsules with inorganic materials

A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be oxygen or water sensitive, to form a microencapsulated material. The microencapsulated material can be formed by microencapsulation methods, which include atomization or coacervation methods, including forming an oil emulsion of an oil phase and an aqueous phase, the oil phase including the core component and the aqueous phase including the polymer material, adding the structuring agent to one of the oil phase and the aqueous phase, mixing the oil emulsion to form desired particle sizes of the core component, forming the shell component around the core component to form the microencapsulated material, and extracting the formed microencapsulated material from the oil emulsion.

Microencapsulation of oxygen or water sensitive materials

Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents

Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

High concentration drag reducing agents may be prepared by microencapsulating and/or macroencapsulating polymer drag reducing agent. The encapsulation may be performed prior to, during, or after the polymerization of monomer into effective drag reducing polymer. If encapsulation is done before or during polymerization, a catalyst may be present, but little or no solvent is required. The result is very small scale bulk polymerization within the capsule. The inert capsule or shell may be removed before, during or after introduction of the encapsulated drag reducer into a flowing liquid. No injection probes or other special equipment is expected to be required to introduce the drag reducing slurry into the liquid stream, nor is grinding (cryogenic or otherwise) of the polymer necessary to form a suitable drag reducing agent.

Microencapsulated and macroencapsulated drag reducing agents

A composite for retarding microbiological contamination containing a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing anions that are capable of reacting with hydronium ions to generate a gas. The hydrophilic and hydrophobic materials are adjacent and substantially free of water, and the hydrophilic material is capable of generating and releasing the gas after hydrolysis of the acid releasing agent.

Compositions for sustained release of a gas

A method of forming polymer beads comprising forming an aqueous solution comprising a cross-linkable water soluble polymer and a water-soluble crosslinking agent, adding said solution with mixing to a thixotropic oil gel comprising an oil in which said polymer is insoluble and a silica or silicate, continuing said mixing for a time sufficient and under conditions sufficient to form a water-in-oil dispersion having individual water/polymer droplets dispersed in said thixotropic oil gel, stopping mixing, and when the droplets are in the form of solid beads recovering the beads from the thixotropic oil gel.

Method for preparing polymeric beads

A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.

Powdered biocidal compositions

Method of making a powdered biocidal composition

A novel plastic composition and method for making the same comprising a host polymer having substantially uniformly distributed therethrough a non-miscible liquid crystal polymer and red amorphous phosphorus. The liquid crystal polymer is present in a concentration sufficient to encapsulate said red amorphous phosphorus such that a substantial portion of the red amorphous phosphorus does not contact the host polymer.

Stabilization of red amorphous phosphorus by ordered polymeric

Encapsulated corn kernels consisting essentially of kernels of corn suitable for popping coated over at least a portion of the outer surface thereof with an edible oleaginous substance or edible wax and thereover with an outer shell comprising an edible polymeric material and an anti-fragility and palatability enhancer; the process of making such encapsulated kernel; and microwaveable pop corn products consisting essentially of the encapsulated corn kernels in a microwaveable package.

Encapsulated corn kernels and method of forming the same

Encapsulated corn kernels consisting essentially of a kernels of corn suitable for popping coated over at least a portion of the outer surface thereof with an edible oleaginous substance or edible wax and thereover with an outer shell of an edible polymer. The process of making such encapsulated kernel; and microwaveable corn products consisting essentially of the encapsulated corn kernels in a microwaveable package.

Growing community of inventors

Floresville, TX, United States of America

Darren E Barlow