The United States of America, as Represented by the Secretary, Department of Health and Human Services

New York University

Darrell T Liu

John B Robbins

Rachel Schneerson

Joanna Kubler-Kielb

Fathy Majadly

Stephen H Leppla

Joseph Shiloach

Louis H Miller

Ruth S Nussenzweig

Jerry Lee Keith

Christopher P Mocca

Zuzana Biesova

Disclosed are immunogenic conjugates which elicit an immune response toproteins. In particular examples, theproteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response toin a subject, comprising administering to the subject an immunogenic composition disclosed herein.

Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia

Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazine-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.

Methods for preparing immunogenic conjugates

Immunogenic compositions and methods for eliciting an immune response againstand other bacilli are provided that include immunogenic conjugates of a poly-&#x3b3;-glutamic acid (&#x3b3;PGA) polypeptide of, or of anotherthat expresses a &#x3b3;PGA polypeptide. The &#x3b3;PGA conjugates elicit an effective immune response against, or against another, in mammalian hosts to which the conjugates are administered.

Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli

Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazino-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.

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Bethesda, MD, United States of America

Darrell T Liu