Zymogenetics, Inc.

Darrell C Conklin

Betty A Haldeman

Theresa A Deisher

Stephen R Jaspers

Paul O Sheppard

Scott R Presnell

Julia E Novak

Angela K Hammond

Si Lok

Zeren Gao

Angelika Grossmann

Thomas R Bukowski

Catherine E Lofton-Day

Susan D Holderman

Fenella C Raymond

Birgit Hansen

Wayne R Kindsvogel

Donald C Foster

Mark W Rixon

Francis J Grant

Rolf E Kuestner

Hal Blumberg

Robyn L Adams

Anna C Jelmberg

Michael R Stamm

Jacqueline M Humes

William Downey

Michele Buddle

Hong Ping Ren

Katherine H Sprugel

Gayle Yamamoto

Jeff Lynn Ellsworth

Mark F Maurer

David W Taft

Theresa M Farrah

Angelika Grossman

Ross C Hoffman

Julia E Parrish

Antibodies that which specifically bind to mammalian cytokine-like polypeptide, called Zcyto10, are described. The antibodies include monoclonal antibodies and those that where the antibody is an antigen-binding fragment. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.

Antibody to human zcyto-10 polypeptide

Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

Methods for producing cytokine receptor ZALPHA11

The present invention relates to zFGF5 compositions and methods of using the compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for treating disorders associated with chondrocytes, such as cartilage injuries and defects. In addition, methods for treating neurological disorders, such as stroke, are disclosed, and methods for using zFGF5 compositions to stimulate growth of cells associated with neurological injury and disease are disclosed.

FGF homologs compositions and uses thereof

The present invention relates to methods of using zFGF5 compositions to proliferate chondrocytes and their progenitors, and to induce deposition of cartilage. zFGF5 compositions are disclosed for treating disorders associated with chondrocytes, such as cartilage injuries and defects. In addition, methods for treating neurological disorders, such as stroke, are disclosed, and methods for using zFGF5 compositions to stimulate growth of cells associated with neurological injury and disease are disclosed.

A mammalian cytokine-like polypeptide, called Zcyto10, polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.

Antibody to human Zcyto10 polypeptide

The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.

Methods of purifying zsig33

Methods for detecting modulators of cytokine receptor zalpha11

Antibodies to cytokine receptor zalpha11

Method of forming a peptide-receptor complex with zsig33

A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.

Antibody to mammalian cytokine-like polypeptide-10

Methods of increasing cartilage deposition using FGF homologs

Polynucleotide encoding mammalian cytokine-like polypeptide-10

The present invention relates to antibodies and fragments thereof, polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.

FGF homologs and antibodies thereto

Polynucleotides encoding cytokine receptor zalpha11

Growing community of inventors

Seattle, WA, United States of America

Darrell C Conklin