Thiogenesis Therapeutics, Inc.

Prochimia Surfaces Sp. Z.o.o.

Dariusz Witt

Piotr Barski

Vincent P Stanton, Jr

Patrice P Rioux

Agnieszka Lindstaedt

Joanna Puzewicz-Barska

The invention features methods for the treatment of cystinosis and other cysteamine sensitive disorders in a subject including administration of a disulfide convertible to cysteamine in vivo. The methods can include the separate administration of a reducing agent to the subject to increase the bioavailablity and extend the plasma pharmacokinetic profile of the cysteamine produced following administration of the disulfide. The methods permit sustained cysteamine plasma concentrations in a subject.

Methods for the treatment of cysteamine sensitive disorders

A method for isolation of 1,3-propanediol from post-fermentation broth is disclosed. The method generally involves the following steps: (1) biomass removal from post-fermentation broth by one of the following methods: ultrafiltration, filtration, centrifugation or sedimentation; (2) 1,3-propanediol extraction with organic solvent mixture containing 2-butanone with high efficiency performed continuously or stepwise; (3) distillation under vacuum to obtain highly pure target product and (4) organic solvent recovery and recycling the solvent back into the process. The method is useful for recovering valuable 1,3-propanediol from aqueous solutions produced by fermentation.

Method for isolation of 1,3-propanediol from post-fermentation broth obtained by bioconversion

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Gdansk, Poland

Dariusz Witt