Ortho-Mcneil Pharmaceutical Corp.

Amgen Inc.

Amgen Sf, LLC

Janssen Pharmaceutica Nv

Darin J Gustin

James Patrick Edwards

Cheryl A Grice

Barbara A Pio

Jianmei Wei

Steven P Meduna

Haripada Khatuya

Hui Cai

Kevin L Tays

J Guy Breitenbucher

Mary Pat Beavers

Julio Cesar Medina

Xiaoqi Chen

Jeffrey Thomas Mihalic

Jason A Duquette

Jeffrey Deignan

Michael G Johnson

Zice Fu

Xiaohui Du

Jiwen Liu

Philippe Bergeron

Frank Kayser

Daqing Sun

Zhihua Ma

Xuelei Yan

David John Kopecky

Yosup Rew

Felix Gonzalez Lopez De Turiso

Brian M Fox

Michael D Bartberger

Xiaodong Wang

John Eksterowicz

Hilary Plake Beck

Steven H Olson

Ana Zurisadai Gonzalez Buenrostro

Richard V Connors

Julie Anne Heath

Zhihong Li

An-Rong Li

Joel McIntosh

Jiasheng Fu

Yihong Li

Philip M Roveto

Andrew P Marcus

Lawrence R McGee

Dustin L McMinn

Ming Yu

Jonathan Dante Low

Brian Stuart Lucas

Yingcai Wang

Lars Karlsson

Clark A Sehon

Robin L Thurmond

XianYun Jiao

Michael W Gribble, Jr

Xin Huang

Jiang Zhu

Benjamin Fisher

SuJen Lai

Siquan Sun

Yin Gu

Christopher R Butler

Michael J Schmitt

Malgorzata Wanska

Christine Weathers

George R Tonn

The present invention provides MDM2 inhibitor compounds of Formula I, 

Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer

The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer

Compounds are provided having the formula: wherein variables R, R, R, R, R, A, A, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases

Provided herein are compounds of the formula where A, A, A, A, L, Q, R, R, R, R, R, R, R, X, Y, Y, Yand Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.

Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders

Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S.

Substituted pyrazoles

Compounds are provided having the formula: wherein variables A, A, A, A, R, R, R, R, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

[object Object]

A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.

Method for treating allergies using substituted pyrazoles

Substituted pyrazoles, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, autoimmune diseases mediated by cathepsin S are described.

Growing community of inventors

Half Moon Bay, CA, United States of America

Darin J Gustin