National Institutes of Health, a Component of the US Dept. of Health & Human Services

Creare, Incorporated

United Technologies Corporation

Centers for Disease Control and Prevention

Darin A Knaus

James J Barry

Mark C Bagley

Mark James Papania

Eric M Friets

Nabil A Elkouh

Robert Trabka

Edward Russell Moynihan

Patrick Magari

Jeffery A Lovett

Scott David Phillips

Daniel J Micka

James Norris

A nasal delivery device can include a nasal prong and an activation member. The nasal prong can have an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Nasal aerosol delivery system

A fuel injection system for a gas turbine engine includes a vane in an airflow path within the gas turbine engine, the vane includes an air channel with an outlet in communication with the airflow path; and a fuel nozzle within the vane operable to inject fuel into the air channel to at least partially premix and prevaporize the fuel with a secondary airflow from within the vane in the air channel prior to entry into the airflow path through the outlet. A method of injecting fuel within a gas turbine engine includes at least partially premixing and prevaporizing fuel with a secondary airflow from within a vane in an air channel within the vane, the vane within an airflow path of the gas turbine engine.

Carbureted fuel injection system for a gas turbine engine

A nasal delivery device can include air-receiving section that has a first passageway therethrough to allow air to pass through the air-receiving section, a powder-reservoir receiving section sized to receive a powder reservoir, and a powder-delivery section that has a second passageway therethrough to allow aerosolized powder from the powder reservoir to pass through the powder-delivery section. The first passageway can have a first end and a second end, with the first end being further from the powder-reservoir receiving section and the second end being at or near the powder-reservoir receiving area. The second end of the air-receiving section can include a flattened region so that air exiting the air-receiving section has a generally flattened profile.

Nasal dry powder delivery system for vaccines and other treatment agents

A nasal delivery device can include a nasal prong and an activation member. The nasal prong can comprises an opening at a top and bottom portion of the prong to allow for the passage of an aerosolized treatment agent through the nasal prong. The activation member can be positioned on the nasal delivery device at a location that is spaced apart from the subject's oral cavity when the nasal prong is received into the nostril of the subject. The activation member can be configured to detect a desired exhalation state of the subject and upon detection of the desired exhalation state, the activation member activates the delivery of the aerosolized treatment agent.

Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.

Aerosol delivery systems and methods

Growing community of inventors

Lyme, NH, United States of America

Darin A Knaus