Applera Corporation

Applied Biosystems, LLC

Life Technologies Corporation

Otonexus Medical Technologies, Inc.

Biodesy, Inc.

Sunflower Therapeutics, Pbc

Other

Bluelight Therapeutics, Inc.

Dar Bahatt

Derek King Prothro

Chirag Patel

Roy Tan

David H Tracy

Yongdong Wang

Paul G Saviano

Jerry E Cahill

Koichi Nishikida

Enrico G Picozza

Mark A Moehring

Louis John Dietz

Joshua S Salafsky

Timothy Z Liu

Daniel Kreindler

Charlie Corredor

Brian Hauser

Chad Jason MacDonald

Jay Patterson

Ray Hebert

Mark F Oldham

Richard T Reel

Timothy M Woudenberg

Jens J Hyldig-Nielsen

Kenneth J Livak

Reid Burton Kowallis

Kevin S Bodner

Charles R Connell

Nigel P Beard

Muhammad A Sharaf

Douglas Greiner

Stephen J Gunstream

H Pin Kao

Konrad Faulstich

Debjyoti Banerjee

Zbignew Bryning

Roy H Tan

Jason E Babcoke

Serguei Ermakov

Chad Jason Macdonald

Joshua Salafsky

Louis J Dietz

Sensor

A device for measuring reflected ultrasound and optical signals may include: an optical source; an optical assembly comprising at least one lens, configured to focus reflected optical illumination from a target onto a detector; and an ultrasound transducer aligned to transmit and receive ultrasound radiation co-axially with the reflected optical illumination and wherein the ultrasound transducer at least partially obstructs a path of the reflected optical illumination. An obstruction may be distant from a focal spot of the optical assembly. The device for measuring reflected ultrasound and optical signals may be particularly useful for characterizing fluid behind an ear drum to diagnose otitis media.

Methods and devices for membrane characterization with ultrasound and optical illumination

Methods, devices, and systems are disclosed for performing high throughput analysis of conformational change in biological molecules or other biological entities using surface-selective nonlinear optical detection techniques.

Systems and methods for high throughput analysis of conformation in biological entities

Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples.

Two-dimensional spectral imaging system

Exemplary embodiments provide microfludic devices and methods for their use. The microfluidic device can include an array of M&#xd7;N reaction sites formed by intersecting a first and second plurality of fluid channels of a flow layer. The flow layer can have a matrix design and/or a blind channel design to analyze a large number of samples under a limited number of conditions. The microfluidic device can also include a control layer including a valve system for regulating solution flow through fluid channels. In addition, by aligning the control layer with the fluid channels, the detection of the microfluidic devices, e.g., optical signal collection, can be improved by piping lights to/from the reaction sites. In an exemplary embodiment, guard channels can be included in the microfluidic device for thermal cycling and/or reducing evaporation from the reaction sites.

Microfluidic devices and method for their use

The present teachings provide a detection cell for a biological material and methods for detecting biological material including a photosensitive material optically coupled to an interior volume containing the biological material so to avoid optical components or an external light source.

Light collection system

Systems, including methods, apparatus, and algorithms, for spectrally imaging a two-dimensional array of samples are disclosed. In one such system, a method of sample analysis includes directing light from a two-dimensional array of examination sites onto a detection area such that dispersed light of known spectral composition from each site falls on the detection area. The method further includes assigning a corresponding two-dimensional array of regions of the detection area for detecting spectra from the examination sites based, at least in part, on the known spectral composition. The method also includes placing samples into the two dimensional array of examination sites and obtaining spectral data for each sample based on the detection area.

Disclosed is a bipolar electrode useful for ECL assays and a method for using the same.

Electrochemiluminescence electrode

A fluid processing device and method of using the device are provided. The fluid processing device can include a substrate with a fluid processing pathway at least partially formed in or on the substrate. The fluid processing pathway can include an input end, at least one output end, a first input opening, a plurality of reaction sites each in fluid communication with the first input opening and arranged between the first input opening and the at least one output end. The fluid processing pathway can include a plurality of second input openings including two or more in fluid communication respectively with each of the reaction sites, the second input openings being arranged with the reaction site disposed between the at least one output end and the second input openings. The fluid processing device can include one or more output openings in fluid communication with one or more of the plurality of reaction sites and arranged at the at least one output end of the fluid processing pathway.

Fluid processing device

Growing community of inventors

Foster City, CA, United States of America

Dar Bahatt