Gilead Sciences, Inc.

Daphne E Kelly

Ernest J Prisbe

John D Munger

Choung U Kim

Matthew A Williams

Lawrence R McGee

John C Rohloff

Lijun Zhang

Kenneth M Kent

Michael J Postich

Murty N Arimilli

Lisa M Schultze

Lawrence V Manes

Thomas T K Lee

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

Preparation of cyclohexene carboxylate derivatives

The invention provides crystalline forms of adefovir dipivoxil and methods to prepare the crystals. The compositions and methods of the present invention have desirable properties for large scale synthesis of crystalline adefovir dipivoxil or for its formulation into therapeutic dosages. Invention compositions include an anhydrous crystal form of adefovir dipivoxil.

Nucleotide analog compositions

The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

Preparation of carbocyclic compounds

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San Francisco, CA, United States of America

Daphne E Kelly