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Insight Strategy Marketing Ltd.

Hadasit Medical Research Services and Development Ltd.

Insight Biopharmacenticals Ltd.

Daphna Miron

Iris Pecker

Maty Ayal-Hershkovitz

Israel Vlodavsky

Yinon Shlomi

Hanna Ben-Artzi

Yoav Peleg

Tuvia Peretz

Yael Friedmann

Oron Yacoby-Zeevi

Ayelet Gilboa

Haim Moskowitz

Madlene Mimon

Madelene Mimon

Yinon Schlomi

A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity.

Heparanase activity neutralizing anti-heparanase monoclonal antibody

A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.

Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.

Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same

Qualitative and quantitative methods of testing an agent for its potential at inhibiting glycosidase catalytic activity, the methods including the steps of interacting a glycosidase enzyme with a glycosidase substrate in a presence of the agent and qualitatively or quantitatively evaluating an effect of the agent on the catalytic activity of the glycosidase enzyme toward the glycosidase substrate. Preferably the glycosidase enzyme is a heparanase enzyme and the glycosidase substrate is, respectively, a heparanase substrate.

Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe

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Rehovot, Israel

Daphna Miron