Shanghai Yao Yuan Biotechnology Co., Ltd.

Celgene Corporation

Danyang Liu

Tian Xu

Xiaodong Chen

Tongruei Raymond Li

Cong Xu

Jieqing Fan

Yanfang Pan

Alexander L Ruchelman

John Fitzgerald Traverse

Gregg Brian Feigelson

Yang Hu

Jihong Liu

Chengjun Ma

Steven Zhang

Shunxiang Zhang

Hongfeng Liu

Zhu Zhu

Juncheng Pan

Yijun Huang

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein.

Compositions and methods of modulating the immune response by activating alpha protein kinase 1

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein. 

Provided herein are processes for preparing an isoindoline-1,3-dione compound, or an enantiomer or a mixture of enantiomers thereof; or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof.

Processes for preparing isoindoline-1,3-dione compounds

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Shanghai, China

Danyang Liu