Azure Biosystems, Inc.

Handyem Inc.

Dany Nolet

Michel Fortin

Alain Chandonnet

The present relates to a chip assembly, a flow cell and a cytometer for characterizing particles in a sample solution. The chip assembly comprises a pair of chips, at least one of the chip defining on its inner surface at least two channels, the two channels defining therebetween a common intersecting area. Each channel is adapted for receiving one or more optical fibers. The chips define a through-hole extending throughout the chip assembly in a transverse direction relative to the channels and passing through the common intersecting area. The flow cell comprises the chip assembly, an excitation fiber and at least one collection fiber extending through respective channels; the collection fiber for collecting light scattered or emitted by particles flowing through the through-hole and excited by an excitation light transported by the excitation fiber. The flow cytometer comprises a light source for generating the excitation light and the flow cell.

Chip assembly, flow cell and flow cytometer for characterizing particles

The present disclosure relates to the field characterization of particles in a sample solution. More specifically, the present disclosure relates to a flow cell and a method for characterizing particles by means of collected non-Gaussian temporal signals. The present flow cell and method rely on an excitation fiber with a channel. The excitation fiber has a core for transporting an excitation light generated by a light source, and defines a channel through a portion of its core. The channel of the excitation fiber directs a flow of the sample solution. The excitation fiber, the channel and collection fibers characteristics are selected, proportioned and positioned to generate collected light with a non-Gaussian temporal intensity profile.

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L'Ancienne-Lorette, Canada

Dany Nolet