Amgen Inc.

Dante Romanini

Pasit Phiasivongsa

Ge Peng

Gary W Luehr

Shabbir T Anik

Irina Dotsenko

Neeraj Jagdish Agrawal

James Richard Falsey

Kevin Graham

Bradley J Herberich

Christopher Mohr

Oliver Thiel

Alex W Jacobitz

Ray Lieh Yoon Low

Victoria Wagner

Stephen Smith

John K Kawooya

The present invention is directed to a CH3-containing molecule comprising (a) a first polypeptide comprising a CH3 domain and a negatively charged domain comprising consecutive negatively charged amino acid residues; and (b) a second polypeptide comprising a CH3 domain and a positively charged domain comprising consecutive positively charged amino acid residues. Also provided are methods for conjugating synthetic molecules to a multi-specific antigen binding molecule.

Bispecific antibodies with cleavable C-terminal charge-paired tags

The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R, R, linker, PEG, n and o are as defined herein.

Pegylated carfilzomib compounds

The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R, R, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.

Growing community of inventors

Sherman Oaks, CA, United States of America

Dante Romanini