Chinese Academy of Sciences

Shanghai Haihe Pharmaceutical Co., Ltd.

Danqi Chen

Meiyu Geng

Jingkang Shen

Xia Peng

Bing Xiong

Yinchun Ji

Xin Wang

Jian Ding

Jia Tao Li

Qi Rong Wang

Jing Ai

Tao Meng

Lanping Ma

Yi Zang

Qian Tan

Jing Al

Yuchi Ma

Yuelei Chen

Ying Dong

Qi Wang

The present disclosure relates to a fused ring pyrimidine amino compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically disclosed in the present disclosure are the compound shown in formula I, a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof, a metabolite thereof, a metabolic precursor thereof, or a prodrug thereof. The fused ring pyrimidine amino compound of the present application has good inhibitory activity against DDRs, particularly DDR2, and has a good therapeutic effect on tumors and fibrotic diseases, especially pulmonary inflammation and pulmonary fibrosis. Also disclosed in the present disclosure are a preparation method for the compound shown in formula I, and a use thereof. 

Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof

This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase. 

Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof

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Shanghai, China

Danqi Chen