Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Danny Mancheno

Philip J Pye

Remy Angelaud

Philip Jones

Linghang Zhuang

Melissa S Egbertson

John S Wai

David Askin

Vincenzo Summa

Ulf H Dolling

Kevin Michael Belyk

R Scott Hoerrner

Hsien-Hsin Tung

Mark Cameron

Debra S Perlow

Wei Han

Daniel J Kumke

Amar J Mahajan

Vanessa Pruzinsky

Lawrence Wai

Henry G Morrison

Rowena D Ruzek

Bruce S Foster

V Brett Cooper

Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.

Process for preparing N-alkylated hydroxypyrimidinone compounds

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. 

HIV integrase inhibitors

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Rego Park, NY, United States of America

Danny Mancheno