Mcdonnell Douglas Corporation

Cutting Edge Optronics, Inc.

H.t. Chemicals, Inc.

Spectraalliance, Inc.

Ninetronix, Inc.

Danny D Meyer

Herbert G Koenig

Louis B Allen, Jr

Dana A Marshall

Yehuda Shalon

Robert C Drews

Tadmor Shalon

Susan L Bragg

Eliezer Pasternak

Robert A Stacy

Ted S McMinn

A method for performing spectral analysis in a pharmaceutical dissolution process. The method comprises inserting a fiber optic probe of a spectral analyzer into a dissolution vessel. The dissolution vessel contains a dissolution medium. The probe has a launch cable, a return cable, a launch lens portion, a return lens portion and a reflector. The reflector is spaced from both the lens portions. The cables, lens portions and reflector are arranged and adapted to form a light pathway whereby light transmitted through the launch cable passes through the launch lens portion, through a volume of the dissolution medium in the spacing between the launch lens portions and the reflector, and then through the return cable. The spacing between the reflector and the lens portions comprise a sample region. The fiber optic probe is sized and adapted to prevent bubbles in the dissolution medium from being trapped in the sample region. The method further comprises transmitting light along the optic pathway, and analyzing the transmitted light for determining certain optical properties of the dissolution medium in the optic pathway.

Method of performing spectral analysis in a pharmaceutical dissolution process

A housing for a slab laser gain media with a rectangular cross section which provides for a uniform flow of coolant over the slab top and bottom surfaces (18) and (20), while insulating the slab side surfaces (14) and (16). The slab gain media is bonded between two tabs at each end of the housing (48a, 48b, 50a, 50b). The slab top and bottom surfaces are made level with the tab top and bottom surfaces. Seals are placed on the continuous surface formed by the slab top and bottom surfaces and the tab top and bottom surfaces, thus sealing the ends of the housing, and also surrounding the coolant inlets and outlets. Windows (32) and (34) are then placed on top of each seal to form two thin cavities confining the coolant to flow across the slab top and bottom surfaces (18) and (20), and allowing for the close-coupling of either one or two pump sources, such as a two dimensional laser diode array assembly (58) and (60).

Housing for a slab laser pumped by a close-coupled light source

This invention relates to high pressure liquid chromatography and to chromatographic columns employed therein. These columns may be modularly modified as to length and/or internal diameter and may contain other components in the modular system, for example, column sections, adapters and cone adapters, for joining column sections of different internal diameters, and end plate units for funnelling in or discharging out fluids; said end caps or lids, with or without funnel shaped means, for facilitating the liquid entrance or exit; and porous frits, with or without handles, all used in conjunction with the column sections to facilitate their usage for performance of specific chromatographic functions. The column sections have terminal flange-like means for accommodating the joining together for formations of a system suitable for high pressure liquid chromatography of the preparative or semi-preparative type.

High pressure liquid chromatography columns

An ophthalmic aspirator and cystotome having a hand-held, motorized instrument which is operated by a battery-run control system. The instrument includes a disposable coaxial aspirator-irrigator tip and a wormdrive mechanism for bidirectional, variable speed operation and also includes a disposable scalpel tip with infusion/irrigation orifice for communication with an intraveneous solution bag. The scalpel tip is coupled through a clutch mechanism to the motor, which may be adjusted by the control system to make single or repeated cuts in either of two rotary directions. The aspirator's most frequently needed controls are mounted on the handpiece to provide an easily operable instrument of great precision for use in eye surgery. The instrument features an electronic control circuit housed in part within a desk top or suspendable unit and in part within the handpiece. The circuit may be switched between the aspirator mode and the cystotome mode and provides control signals to a motor carried within the handpiece. In the aspirator mode the circuit generates aspirate and backflush signals at the touch of a control switch mounted on the handpiece. Flow rates are continuously variable by means of a potentiometer control in the butt of the handpiece. In the cystotome mode the control switch commands either single cutting strokes or repeated cutting strokes in either of two rotary directions, the direction being selected by the potentiometer control.

Ophthalmic aspirator/irrigator and cystotome

A laser diode is soldered between metal plates for intimate thermal and electrical contact. The plates are prefabricated and are provided with an insulative spacer therebetween. The two metal plates are held together in a preferred orientation by the spacer which is firmly adhered and sealed to the two plates during the diode soldering operation. The metal plates are constructed from material thin enough that they yield under thermal pressure of the diode to eliminate mechanical strain on the diode during thermal cycling. Backup plates are provided in contact with the diode mounting plates to feed electrical energy thereto.

Laser diode with double sided heat sink

A laser diode is soldered between metal plates for intimate thermal and electrical contact. The plates are prefabricated and are provided with an insulated spacer therebetween. The two metal plates are held together in a preferred orientation by the spacer which is firmly adhered and sealed to the two plates during the diode soldering operation. The laser diodes so mounted can be tested in this configuration and after testing are formed into an array by stacking the laser diode subassemblies providing spacer elements therebetween and series contacts from one end to the other of the array so that an array of laser diodes with matched characteristics can be constructed in a line which may not be in alignment with the total package to provide an intense light output at a predetermined wavelength.

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St. Louis, MO, United States of America

Danny D Meyer