Liposome Technology, Inc.

Other

Alza Corporation

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Sequus Pharmaceuticals, Inc.

Danilo D Lasic

Francis J Martin

Samuel Zalipsky

Martin C Woodle

Yechezkel Barenholz

Brian Charles Keller

Robert M Abra

Alenka Lasic, Legal Representative

Andrej Belic

Tal Peleg-Shulman

A liposome composition having a compound entrapped in a supersaturated solution and method for preparing such a composition are described.

Liposomes containing an entrapped compound in supersaturated solution

Certain diacylglycerol-polyethyleneglycol (DAG-PEG) lipids are especially useful for forming thermodynamically stable liposomes. Such liposomes are useful for a variety of purposes, including the delivery of therapeutic agents.

Self forming, thermodynamically stable liposomes and their applications

A lipid-polymer conjugate for use in forming long-circulating liposomes is disclosed. The conjugate includes a vesicle-forming lipid having covalently attached to its polar head group, one of the polymers: polyvinylpyrrolidone, polyvinylmethylether, polyhydroxypropyl methacrylate, polyhydroxypropylmethacrylamide, polyhydroxyethyl acrylate, polymethacrylamide, polydimethylacrylamide, polymethyloxazoline, polyethyloxazoline, polyhydroxyethyloxazoline, polyhydroxypropyloxazoline, or polyaspartamide. A method for preparing liposomes containing the lipid-polymer conjugate is also disclosed.

Lipid-polymer conjugates and liposomes

This invention describes a simple, fast, reproducible economic, and convenient method of preparation of very large unilamellar liposome vesicles of uniform size distribution. The populations of these vesicles are homogeneous and suitable for encapsulation of water and lipid soluble compounds.

Method for instant preparation of a drug containing large unilamellar

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Newark, CA, United States of America

Danilo D Lasic