Biolitec Pharma Marketing Ltd

Bioliter Pharme Marketing Ltd

Danilo Castro

Wolfgang Neuberger

Volker Albrecht

Susanna Gräfe

Innovative non-surgical methods and compositions are provided for administering PDT to promote tissue regeneration or augmentation while minimizing scarring and risk of infection. Among several areas of application, is the treatment of acute and chronic wounds which have afflicted epidermal and connective tissue layers of the body. Another application area is as cosmetic surgery/treatments, including: reducing wrinkles, sulcus, scars (acne or traumatic caused), sequelae cellulite, as well as for other skin irregularities, to give a smoother skin surface. This invention consists of a collagen based or other suitable biodegradable supporting matrix which is embedded with a liposomal loaded photosensitizer. In one embodiment of this invention a liposomal formulated photosensitizer is first injected at the site followed by collagen implantation and PDT treatment. In another embodiment a liposomal formulated photosensitizer is incorporated in the collagen. Generally 30 minutes after collagen is mixed with photosensitizer the light activation is done. The matrix may also carry important growth factors and cytokines, which promote fibroblast cell migration and proliferation, to the wound site. Microbial infection at the wound site can also be controlled by antibacterial PDT.

Photodynamic cosmetic procedure and healing method

A PhotoDynamic Therapy (PDT) method is presented for cosmetic rejuvenation, which is exemplified by a two phase approach for treating facial and neck skin aging while minimizing damage to the underlying region of skin being treated. To obtain best results a combination of treatments are used. This includes applying photosensitizer and light energy for stimulating the collagen within the skin, thereby restoring the elasticity of skin. The treatment procedures take about six weeks consisting of impair (damage) and repair (recovery) sessions involving skin preparation by peeling, skin detoxification, application and distribution of photosensitizer to the skin, irradiation of pre-sensitized skin followed by removal of mask. Results of long lasting improvement, especially in comparison with most cosmetic treatments, are obtained upon completion of the series, with marked changes being observed after individual sessions, which provide added incentive to complete a treatment program. These results eliminate the need for repetitive treatments after the six week series, unlike most current approaches which require repeat sessions semi-annually or annually.

Cosmetic rejuvenation by photodynamic therapy

Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys 'fat' cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.

PDT treatment method for cellulites and cosmetic use

A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.

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Montevideo, Uruguay

Danilo Castro