Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa

Instituto Di Ricerche Di Biologia Molecolare P. Angeletti S.r.l.

Msd Italia S.r.l.

Danila Branca

Philip Jones

Rita Scarpelli

Jesus Maria Ontoria Ontoria

Giovanna Pescatore

Ester Muraglia

Olaf Kinzel

Federica Ferrigno

Carsten Schultz-Fademrecht

Savina Malancona

Maria Cecilia Palumbi

Gabriella Dessole

Jose Ignacio Martin Hernando

Samuele Lillini

Jose Ignacio Hernando

Julia Kay Boueres

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract. 

Saturated bicyclic heterocyclic derivatives as SMO antagonists

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. 

Pyridazinone derivatives as PARP inhibitors

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Rome, Italy

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